Literature DB >> 22126725

Colorectal cancer stem cell: a potential therapeutic target.

H Tao1, Y Zhu.   

Abstract

The discovery of cancer stem cells has improved our understanding of tumour occurrence and development. Colorectal cancer stem cells may be derived from mutations in normal intestinal epithelial stem cells. CD133+ and aldehyde dehydrogenase 1 (ALDH1)+ cells have strong tumorigenic capacities and may represent different subpopulations of colorectal cancer stem cells. Multiple signalling pathways, especially the Wnt pathway, are important in colorectal cancer occurrence and development, and maintaining the stemness of colorectal cancer stem cells. Identifying colorectal cancer stem cells and understanding the related signalling pathways are important for developing new targeted interventions for colorectal cancer.

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Year:  2011        PMID： 22126725     DOI： 10.1007/s12094-011-0743-5

Source DB:  PubMed          Journal:  Clin Transl Oncol        ISSN： 1699-048X            Impact factor:   3.405


  49 in total

1.  Tracking down the stem cells of the intestine: strategies to identify adult stem cells.

Authors:  Nick Barker; Hans Clevers
Journal:  Gastroenterology       Date:  2007-12       Impact factor: 22.682

2.  Bmi1 is expressed in vivo in intestinal stem cells.

Authors:  Eugenio Sangiorgi; Mario R Capecchi
Journal:  Nat Genet       Date:  2008-06-08       Impact factor: 38.330

3.  An orphan nuclear receptor finds a home.

Authors:  Alan R Kimmel
Journal:  Mol Cell       Date:  2010-01-29       Impact factor: 17.970

Review 4.  Stem cells and their implications for colorectal cancer.

Authors:  Sebastian S Zeki; Trevor A Graham; Nicholas A Wright
Journal:  Nat Rev Gastroenterol Hepatol       Date:  2011-02       Impact factor: 46.802

5.  The stem cells of small intestinal crypts: where are they?

Authors:  C S Potten; R Gandara; Y R Mahida; M Loeffler; N A Wright
Journal:  Cell Prolif       Date:  2009-09-28       Impact factor: 6.831

6.  Efficient killing of human colon cancer stem cells by gammadelta T lymphocytes.

Authors:  Matilde Todaro; Matilde D'Asaro; Nadia Caccamo; Flora Iovino; Maria Giovanna Francipane; Serena Meraviglia; Valentina Orlando; Carmela La Mendola; Gaspare Gulotta; Alfredo Salerno; Francesco Dieli; Giorgio Stassi
Journal:  J Immunol       Date:  2009-06-01       Impact factor: 5.422

7.  An anti-Wnt-2 monoclonal antibody induces apoptosis in malignant melanoma cells and inhibits tumor growth.

Authors:  Liang You; Biao He; Zhidong Xu; Kazutsugu Uematsu; Julien Mazieres; Naoaki Fujii; Iwao Mikami; Noemi Reguart; Joe K McIntosh; Mohammed Kashani-Sabet; Frank McCormick; David M Jablons
Journal:  Cancer Res       Date:  2004-08-01       Impact factor: 12.701

8.  Aldehyde dehydrogenase 1 is a marker for normal and malignant human colonic stem cells (SC) and tracks SC overpopulation during colon tumorigenesis.

Authors:  Emina H Huang; Mark J Hynes; Tao Zhang; Christophe Ginestier; Gabriela Dontu; Henry Appelman; Jeremy Z Fields; Max S Wicha; Bruce M Boman
Journal:  Cancer Res       Date:  2009-03-31       Impact factor: 12.701

9.  Identification of stem cells in small intestine and colon by marker gene Lgr5.

Authors:  Nick Barker; Johan H van Es; Jeroen Kuipers; Pekka Kujala; Maaike van den Born; Miranda Cozijnsen; Andrea Haegebarth; Jeroen Korving; Harry Begthel; Peter J Peters; Hans Clevers
Journal:  Nature       Date:  2007-10-14       Impact factor: 49.962

10.  Phenotypic characterization of human colorectal cancer stem cells.

Authors:  Piero Dalerba; Scott J Dylla; In-Kyung Park; Rui Liu; Xinhao Wang; Robert W Cho; Timothy Hoey; Austin Gurney; Emina H Huang; Diane M Simeone; Andrew A Shelton; Giorgio Parmiani; Chiara Castelli; Michael F Clarke
Journal:  Proc Natl Acad Sci U S A       Date:  2007-06-04       Impact factor: 11.205
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  2 in total

1.  Identification of Growth Factors, Cytokines and Mediators Regulated by Artemisia annua L. Polyphenols (pKAL) in HCT116 Colorectal Cancer Cells: TGF-β1 and NGF-β Attenuate pKAL-Induced Anticancer Effects via NF-κB p65 Upregulation.

Authors:  Eun Joo Jung; Anjugam Paramanantham; Hye Jung Kim; Sung Chul Shin; Gon Sup Kim; Jin-Myung Jung; Soon Chan Hong; Ky Hyun Chung; Choong Won Kim; Won Sup Lee
Journal:  Int J Mol Sci       Date:  2022-01-29       Impact factor: 5.923

2.  siRNA-induced CD44 knockdown suppresses the proliferation and invasion of colorectal cancer stem cells through inhibiting epithelial-mesenchymal transition.

Authors:  Weiyan Zou; Yi Zhang; Guangfu Bai; Jialu Zhuang; Lin Wei; Zishu Wang; Meiqun Sun; Junbin Wang
Journal:  J Cell Mol Med       Date:  2022-03-01       Impact factor: 5.310
  2 in total

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