OBJECTIVES: To evaluate the immunohistochemical expression of estrogen receptors (ER) and progesterone receptors (PR) in colorectal adenoma and adenocarcinoma and to correlate this immunohistochemical expression with different clinicopathological parameters. METHODS: The study was retrospectively designed. A total of 86 tissue samples, including 33 paraffin blocks from patients with colorectal adenomas, 33 paraffin blocks from patients with colorectal adenocarcinomas and a control group of 20 samples of non-tumorous colonic tissue, were included in the study. RESULTS: The frequency of expression of ER and PR showed a gradual increase from control through adenoma to carcinoma. The frequencies of expression of ER in the control, adenoma and carcinoma were (10%, 15.15% and 42.42% respectively, p<0.001), while the frequency of expression for PR were (10%, 24.24% and 36.36% respectively, p<0.001). Strong ER and PR staining was mainly seen in carcinoma cases (42.42%, 36.36%, respectively) in comparison with adenoma (9.09%, 15.15%, respectively) and control (0%, 0%, respectively). The three digital parameters of ER and PR immunohistochemical expression (Area [A], Number of objects [N], and intensity [I]) were significantly increased in a sequence of normal mucosa-adenoma-carcinoma. There was a significant positive correlation between ER and PR in adenoma (r=0.312, p=0.034) and carcinoma (r=0.321, p=0.0398). CONCLUSION: ER and PR expression increased in a sequence of; normal colonic mucosa-adenoma-carcinoma, and a positive correlation was observed between ER and PR expression in colonic adenoma and carcinoma specimen indicating that ER and PR may play a role in colorectal carcinogenesis.
OBJECTIVES: To evaluate the immunohistochemical expression of estrogen receptors (ER) and progesterone receptors (PR) in colorectal adenoma and adenocarcinoma and to correlate this immunohistochemical expression with different clinicopathological parameters. METHODS: The study was retrospectively designed. A total of 86 tissue samples, including 33 paraffin blocks from patients with colorectal adenomas, 33 paraffin blocks from patients with colorectal adenocarcinomas and a control group of 20 samples of non-tumorous colonic tissue, were included in the study. RESULTS: The frequency of expression of ER and PR showed a gradual increase from control through adenoma to carcinoma. The frequencies of expression of ER in the control, adenoma and carcinoma were (10%, 15.15% and 42.42% respectively, p<0.001), while the frequency of expression for PR were (10%, 24.24% and 36.36% respectively, p<0.001). Strong ER and PR staining was mainly seen in carcinoma cases (42.42%, 36.36%, respectively) in comparison with adenoma (9.09%, 15.15%, respectively) and control (0%, 0%, respectively). The three digital parameters of ER and PR immunohistochemical expression (Area [A], Number of objects [N], and intensity [I]) were significantly increased in a sequence of normal mucosa-adenoma-carcinoma. There was a significant positive correlation between ER and PR in adenoma (r=0.312, p=0.034) and carcinoma (r=0.321, p=0.0398). CONCLUSION: ER and PR expression increased in a sequence of; normal colonic mucosa-adenoma-carcinoma, and a positive correlation was observed between ER and PR expression in colonic adenoma and carcinoma specimen indicating that ER and PR may play a role in colorectal carcinogenesis.
Authors: S Wang; M H Saboorian; E P Frenkel; B B Haley; M T Siddiqui; S Gokaslan; F H Wians; L Hynan; R Ashfaq Journal: Am J Clin Pathol Date: 2001-10 Impact factor: 2.493
Authors: F Grodstein; M E Martinez; E A Platz; E Giovannucci; G A Colditz; M Kautzky; C Fuchs; M J Stampfer Journal: Ann Intern Med Date: 1998-05-01 Impact factor: 25.391
Authors: I G Kaklamanos; O F Bathe; D Franceschi; A C Lazaris; P Davaris; M Glinatsis; B C Golematis Journal: J Surg Oncol Date: 1999-12 Impact factor: 3.454
Authors: Nancy L Cho; Sara H Javid; Adelaide M Carothers; Mark Redston; Monica M Bertagnolli Journal: Cancer Res Date: 2007-03-01 Impact factor: 12.701
Authors: M Marugo; F Molinari; L Fazzuoli; M C Parodi; D Bernasconi; F Menozzi; G Giordano Journal: J Endocrinol Invest Date: 1985-04 Impact factor: 4.256
Authors: Alicia G Cleveland; Seija I Oikarinen; Kimberly K Bynoté; Maija Marttinen; Joseph J Rafter; Jan-Ake Gustafsson; Shyamal K Roy; Henry C Pitot; Kenneth S Korach; Dennis B Lubahn; Marja Mutanen; Karen A Gould Journal: Carcinogenesis Date: 2009-06-11 Impact factor: 4.944