Literature DB >> 22125346

New ways to derivatize at position 6 of 7,7-dimethyl-7,8-dihydropterin.

Genbin Shi1, Xinhua Ji.   

Abstract

Reported are the synthesis of two intermediates for derivatization at position 6 of 7,7-dimethyl-7,8-dihydropterin: 6-carboxylic acid ethyl ester-7,7-dimethyl-7,8-dihydropterin, which is a novel compound, and 6-aldehyde-7,7-dimethyl-7,8-dihydropterin, which is synthesized by a new method with a yield of 90%.

Entities:  

Year:  2011        PMID： 22125346      PMCID： PMC3224078          DOI： 10.1016/j.tetlet.2011.09.047

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  12 in total

Review 1.  The folic acid biosynthesis pathway in bacteria: evaluation of potential for antibacterial drug discovery.

Authors:  Alun Bermingham; Jeremy P Derrick
Journal:  Bioessays       Date:  2002-07       Impact factor: 4.345

Review 2.  DNA and RNA synthesis: antifolates.

Authors:  Ivan M Kompis; Khalid Islam; Rudolf L Then
Journal:  Chem Rev       Date:  2005-02       Impact factor: 60.622

Review 3.  The structure and mechanism of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.

Authors:  Jeremy P Derrick
Journal:  Vitam Horm       Date:  2008       Impact factor: 3.421

4.  Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: synthesis and biochemical and crystallographic studies.

Authors:  G Shi; J Blaszczyk; X Ji; H Yan
Journal:  J Med Chem       Date:  2001-04-26       Impact factor: 7.446

5.  The structure and function of the 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Haemophilus influenzae.

Authors:  M Hennig; G E Dale; A D'arcy; F Danel; S Fischer; C P Gray; S Jolidon; F Müller; M G Page; P Pattison; C Oefner
Journal:  J Mol Biol       Date:  1999-03-26       Impact factor: 5.469

6.  Catalytic center assembly of HPPK as revealed by the crystal structure of a ternary complex at 1.25 A resolution.

Authors:  J Blaszczyk; G Shi; H Yan; X Ji
Journal:  Structure       Date:  2000-10-15       Impact factor: 5.006

Review 7.  Role of protein conformational dynamics in the catalysis by 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.

Authors:  Honggao Yan; Xinhua Ji
Journal:  Protein Pept Lett       Date:  2011-04       Impact factor: 1.890

8.  Toward a general synthesis of chlorins.

Authors:  William G O'Neal; Peter A Jacobi
Journal:  J Am Chem Soc       Date:  2008-01-01       Impact factor: 15.419

9.  Reaction trajectory of pyrophosphoryl transfer catalyzed by 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase.

Authors:  Jaroslaw Blaszczyk; Genbin Shi; Yue Li; Honggao Yan; Xinhua Ji
Journal:  Structure       Date:  2004-03       Impact factor: 5.006

10.  6-Acetyl-7,7-dimethyl-5,6,7,8-tetrahydropterin is an activator of nitric oxide synthases.

Authors:  Colin J Suckling; Colin L Gibson; Judith K Huggan; Raghavendar R Morthala; Brendan Clarke; Suma Kununthur; Roger M Wadsworth; Simon Daff; Davide Papale
Journal:  Bioorg Med Chem Lett       Date:  2008-01-30       Impact factor: 2.823
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  2 in total

1.  Bisubstrate analogue inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: New design with improved properties.

Authors:  Genbin Shi; Gary Shaw; Yu-He Liang; Priadarsini Subburaman; Yue Li; Yan Wu; Honggao Yan; Xinhua Ji
Journal:  Bioorg Med Chem       Date:  2011-11-23       Impact factor: 3.641

2.  Bisubstrate analog inhibitors of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase: new lead exhibits a distinct binding mode.

Authors:  Genbin Shi; Gary Shaw; Yue Li; Yan Wu; Honggao Yan; Xinhua Ji
Journal:  Bioorg Med Chem       Date:  2012-06-06       Impact factor: 3.641
  2 in total

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