Literature DB >> 22124229

Proteomic profiling and potential cellular target identification of K11777, a clinical cysteine protease inhibitor, in Trypanosoma brucei.

Peng-Yu Yang1, Min Wang, Cynthia Y He, Shao Q Yao.   

Abstract

We report herein the design, synthesis and application of K11777-derived activity-based probes (ABPs) allowing in situ profiling and identification of potential cellular targets of K11777 in Trypanosoma brucei. This journal is © The Royal Society of Chemistry 2012

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Year:  2011        PMID： 22124229     DOI： 10.1039/c1cc16178d

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  12 in total

1.  Peptidomimetic Vinyl Heterocyclic Inhibitors of Cruzain Effect Antitrypanosomal Activity.

Authors:  Bala C Chenna; Linfeng Li; Drake M Mellott; Xiang Zhai; Jair L Siqueira-Neto; Claudia Calvet Alvarez; Jean A Bernatchez; Emily Desormeaux; Elizabeth Alvarez Hernandez; Jana Gomez; James H McKerrow; Jorge Cruz-Reyes; Thomas D Meek
Journal:  J Med Chem       Date:  2020-03-17       Impact factor: 7.446

2.  Strain Promoted Click Chemistry of 2- or 8-Azidopurine and 5-Azidopyrimidine Nucleosides and 8-Azidoadenosine Triphosphate with Cyclooctynes. Application to Living Cell Fluorescent Imaging.

Authors:  Jessica Zayas; Marie Annoual; Jayanta Kumar Das; Quentin Felty; Walter G Gonzalez; Jaroslava Miksovska; Nima Sharifai; Akira Chiba; Stanislaw F Wnuk
Journal:  Bioconjug Chem       Date:  2015-07-02       Impact factor: 4.774

3.  Development of a New Antileishmanial Aziridine-2,3-Dicarboxylate-Based Inhibitor with High Selectivity for Parasite Cysteine Proteases.

Authors:  Caroline Schad; Ulrike Baum; Benjamin Frank; Uwe Dietzel; Felix Mattern; Carlos Gomes; Alicia Ponte-Sucre; Heidrun Moll; Uta Schurigt; Tanja Schirmeister
Journal:  Antimicrob Agents Chemother       Date:  2015-11-23       Impact factor: 5.191

4.  Identification of plakortide E from the Caribbean sponge Plakortis halichondroides as a trypanocidal protease inhibitor using bioactivity-guided fractionation.

Authors:  Swarna Oli; Usama Ramadan Abdelmohsen; Ute Hentschel; Tanja Schirmeister
Journal:  Mar Drugs       Date:  2014-05-02       Impact factor: 5.118

5.  In situ Proteomic Profiling of Curcumin Targets in HCT116 Colon Cancer Cell Line.

Authors:  Jigang Wang; Jianbin Zhang; Chong-Jing Zhang; Yin Kwan Wong; Teck Kwang Lim; Zi-Chun Hua; Bin Liu; Steven R Tannenbaum; Han-Ming Shen; Qingsong Lin
Journal:  Sci Rep       Date:  2016-02-26       Impact factor: 4.379

6.  Naphthoquinones as Covalent Reversible Inhibitors of Cysteine Proteases-Studies on Inhibition Mechanism and Kinetics.

Authors:  Philipp Klein; Fabian Barthels; Patrick Johe; Annika Wagner; Stefan Tenzer; Ute Distler; Thien Anh Le; Paul Schmid; Volker Engel; Bernd Engels; Ute A Hellmich; Till Opatz; Tanja Schirmeister
Journal:  Molecules       Date:  2020-04-28       Impact factor: 4.411

Review 7.  Experimental Strategies to Explore Drug Action and Resistance in Kinetoplastid Parasites.

Authors:  Magali Van den Kerkhof; Yann G-J Sterckx; Philippe Leprohon; Louis Maes; Guy Caljon
Journal:  Microorganisms       Date:  2020-06-24

8.  Characterization of P. falciparum dipeptidyl aminopeptidase 3 specificity identifies differences in amino acid preferences between peptide-based substrates and covalent inhibitors.

Authors:  Laura E de Vries; Mateo I Sanchez; Katarzyna Groborz; Laurie Kuppens; Marcin Poreba; Christine Lehmann; Neysa Nevins; Chrislaine Withers-Martinez; David J Hirst; Fang Yuan; Shirin Arastu-Kapur; Martin Horn; Michael Mares; Matthew Bogyo; Marcin Drag; Edgar Deu
Journal:  FEBS J       Date:  2019-06-24       Impact factor: 5.542

9.  Chemical-biological characterization of a cruzain inhibitor reveals a second target and a mammalian off-target.

Authors:  Jonathan W Choy; Clifford Bryant; Claudia M Calvet; Patricia S Doyle; Shamila S Gunatilleke; Siegfried S F Leung; Kenny K H Ang; Steven Chen; Jiri Gut; Juan A Oses-Prieto; Jonathan B Johnston; Michelle R Arkin; Alma L Burlingame; Jack Taunton; Matthew P Jacobson; James M McKerrow; Larissa M Podust; Adam R Renslo
Journal:  Beilstein J Org Chem       Date:  2013-01-04       Impact factor: 2.883

10.  A cysteine protease inhibitor blocks SARS-CoV-2 infection of human and monkey cells.

Authors:  Drake M Mellott; Chien-Te Tseng; Aleksandra Drelich; Pavla Fajtová; Bala C Chenna; Demetrios H Kostomiris; Jason Hsu; Jiyun Zhu; Zane W Taylor; Vivian Tat; Ardala Katzfuss; Linfeng Li; Miriam A Giardini; Danielle Skinner; Ken Hirata; Sungjun Beck; Aaron F Carlin; Alex E Clark; Laura Beretta; Daniel Maneval; Felix Frueh; Brett L Hurst; Hong Wang; Klaudia I Kocurek; Frank M Raushel; Anthony J O'Donoghue; Jair Lage de Siqueira-Neto; Thomas D Meek; James H McKerrow
Journal:  bioRxiv       Date:  2020-10-30
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