Literature DB >> 22123295

Activation of the aryl hydrocarbon receptor represses mammosphere formation in MCF-7 cells.

Shuai Zhao1, Yuichiro Kanno, Momoka Nakayama, Minami Makimura, Shiori Ohara, Yoshio Inouye.   

Abstract

The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor. Recent studies have reported the anti-tumor effects of the AhR in breast cancer. In this study, we investigated the anti-tumor effect of AhR activation based on the cancer stem cell hypothesis. We show that AhR activation suppressed mammosphere formation of MCF-7 cells and decreased the proportion of cells with high ALDH-1 (aldehyde dehydrogenase 1) activity. In addition, we also demonstrate that AhR activation regulates self-renewal signaling by down-regulating Wnt/β-catenin and Notch.
Copyright © 2011 Elsevier Ireland Ltd. All rights reserved.

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Year:  2011        PMID： 22123295     DOI： 10.1016/j.canlet.2011.11.025

Source DB:  PubMed          Journal:  Cancer Lett        ISSN： 0304-3835            Impact factor:   8.679


  18 in total

1.  In silico identification of an aryl hydrocarbon receptor antagonist with biological activity in vitro and in vivo.

Authors:  Ashley J Parks; Michael P Pollastri; Mark E Hahn; Elizabeth A Stanford; Olga Novikov; Diana G Franks; Sarah E Haigh; Supraja Narasimhan; Trent D Ashton; Timothy G Hopper; Dmytro Kozakov; Dimitri Beglov; Sandor Vajda; Jennifer J Schlezinger; David H Sherr
Journal:  Mol Pharmacol       Date:  2014-08-26       Impact factor: 4.436

2.  Resveratrol and its methoxy derivatives modulate the expression of estrogen metabolism enzymes in breast epithelial cells by AhR down-regulation.

Authors:  Barbara Licznerska; Hanna Szaefer; Marcin Wierzchowski; Hanna Sobierajska; Wanda Baer-Dubowska
Journal:  Mol Cell Biochem       Date:  2016-11-16       Impact factor: 3.396

3.  Role of AhR in regulating cancer stem cell-like characteristics in choriocarcinoma.

Authors:  Chenchun Wu; Shuran Yu; Qianxia Tan; Peng Guo; Huining Liu
Journal:  Cell Cycle       Date:  2018-10-18       Impact factor: 4.534

4.  AhR expression is increased in hepatocellular carcinoma.

Authors:  Ziyu Liu; Xing'an Wu; Fanglin Zhang; Lurong Han; Guoqiang Bao; Xianli He; Zhikai Xu
Journal:  J Mol Histol       Date:  2013-04-02       Impact factor: 2.611

5.  Camalexin, an indole phytoalexin, inhibits cell proliferation, migration, and mammosphere formation in breast cancer cells via the aryl hydrocarbon receptor.

Authors:  Naoya Yamashita; Chiharu Taga; Moeno Ozawa; Yuichiro Kanno; Noriko Sanada; Ryoichi Kizu
Journal:  J Nat Med       Date:  2021-08-31       Impact factor: 2.343

Review 6.  Role of the aryl hydrocarbon receptor in carcinogenesis and potential as a drug target.

Authors:  Stephen Safe; Syng-Ook Lee; Un-Ho Jin
Journal:  Toxicol Sci       Date:  2013-06-14       Impact factor: 4.849

7.  ent-Atisane diterpenoids from Euphorbia fischeriana inhibit mammosphere formation in MCF-7 cells.

Authors:  Xinzhu Kuang; Wei Li; Yuichiro Kanno; Naoya Yamashita; Kiyomitsu Nemoto; Yoshihisa Asada; Kazuo Koike
Journal:  J Nat Med       Date:  2015-09-28       Impact factor: 2.343

8.  Euphorins A-H: bioactive diterpenoids from Euphorbia fischeriana.

Authors:  Xinzhu Kuang; Wei Li; Yuichiro Kanno; Naoya Yamashita; Shoko Kikkawa; Isao Azumaya; Kiyomitsu Nemoto; Yoshihisa Asada; Kazuo Koike
Journal:  J Nat Med       Date:  2016-03-21       Impact factor: 2.343

Review 9.  Converging Roles of the Aryl Hydrocarbon Receptor in Early Embryonic Development, Maintenance of Stemness, and Tissue Repair.

Authors:  Hesbon A Zablon; Chia-I Ko; Alvaro Puga
Journal:  Toxicol Sci       Date:  2021-07-16       Impact factor: 4.849

10.  Cancer stem cells: Culprits in endocrine resistance and racial disparities in breast cancer outcomes.

Authors:  Nicole Mavingire; Petreena Campbell; Jonathan Wooten; Joyce Aja; Melissa B Davis; Andrea Loaiza-Perez; Eileen Brantley
Journal:  Cancer Lett       Date:  2020-12-09       Impact factor: 8.679
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