BACKGROUND: Metastatic renal cell carcinoma (RCC) presents a therapeutic challenge for clinicians because of the unpredictable clinical course, resistance to chemotherapy or radiotherapy and the limited response to immunotherapy. PATIENTS AND METHODS: We report a case of a 62-year-old woman who underwent nephrectomy for T4N0 RCC, clear cell type, Fuhrman grade 3/4 in 1999. The patient subsequently had multiple tumor recurrences. RESULTS: The patient underwent eight metastasectomies, including multiple partial left nephrectomies, right adrenalectomy, a complete left nephrectomy, and distal pancreatectomy. She remains well and tumor free 12 years after initial diagnosis. CONCLUSION: Repeated resections after initial metastasectomy can be carried out safely and provide long-term survival in selected patients with recurrent metastasis from RCC. The findings from our case indicate that close follow-up for the early detection of recurrence and complete resection of metastases can improve the results after repeated resection.
BACKGROUND:Metastatic renal cell carcinoma (RCC) presents a therapeutic challenge for clinicians because of the unpredictable clinical course, resistance to chemotherapy or radiotherapy and the limited response to immunotherapy. PATIENTS AND METHODS: We report a case of a 62-year-old woman who underwent nephrectomy for T4N0 RCC, clear cell type, Fuhrman grade 3/4 in 1999. The patient subsequently had multiple tumor recurrences. RESULTS: The patient underwent eight metastasectomies, including multiple partial left nephrectomies, right adrenalectomy, a complete left nephrectomy, and distal pancreatectomy. She remains well and tumor free 12 years after initial diagnosis. CONCLUSION: Repeated resections after initial metastasectomy can be carried out safely and provide long-term survival in selected patients with recurrent metastasis from RCC. The findings from our case indicate that close follow-up for the early detection of recurrence and complete resection of metastases can improve the results after repeated resection.
Authors: Jose A Karam; Brian I Rini; Leticia Varella; Jorge A Garcia; Robert Dreicer; Toni K Choueiri; Eric Jonasch; Surena F Matin; Steven C Campbell; Christopher G Wood; Nizar M Tannir Journal: J Urol Date: 2010-12-17 Impact factor: 7.450
Authors: R Ghavamian; K A Klein; D H Stephens; T J Welch; A J LeRoy; R L Richardson; P A Burch; H Zincke Journal: Mayo Clin Proc Date: 2000-06 Impact factor: 7.616
Authors: Angela L Alt; Stephen A Boorjian; Christine M Lohse; Brian A Costello; Bradley C Leibovich; Michael L Blute Journal: Cancer Date: 2011-01-10 Impact factor: 6.860
Authors: Krzysztof Ratajczyk; Andrzej Konieczny; Adrian Czekaj; Paweł Piotrów; Marek Fiutowski; Kornelia Krakowska; Paweł Kowal; Wojciech Witkiewicz; Karolina Marek-Bukowiec Journal: Int J Environ Res Public Health Date: 2022-08-11 Impact factor: 4.614