Leon A Bach1. 1. Department of Endocrinology and Diabetes, The Alfred, Melbourne, Australia. leon.bach@monash.edu
Abstract
PURPOSE OF REVIEW: The insulin-like growth factor system plays an important role in renal physiology and it is perturbed in a range of kidney diseases. RECENT FINDINGS: Some insulin-like growth factor (IGF) actions in the kidney are mediated by nitric oxide. Growth hormone and IGF-binding proteins may contribute to renal diseases via effects on podocytes and proximal tubule cells. In contrast, growth hormone and IGF-I may counteract the catabolic consequences of end-stage renal disease. Polymorphisms in the IGF system are associated with hypertension. SUMMARY: Further studies are needed to determine whether modulating the IGF system may have a role in treating kidney diseases and/or hypertension.
PURPOSE OF REVIEW: The insulin-like growth factor system plays an important role in renal physiology and it is perturbed in a range of kidney diseases. RECENT FINDINGS: Some insulin-like growth factor (IGF) actions in the kidney are mediated by nitric oxide. Growth hormone and IGF-binding proteins may contribute to renal diseases via effects on podocytes and proximal tubule cells. In contrast, growth hormone and IGF-I may counteract the catabolic consequences of end-stage renal disease. Polymorphisms in the IGF system are associated with hypertension. SUMMARY: Further studies are needed to determine whether modulating the IGF system may have a role in treating kidney diseases and/or hypertension.
Authors: Jessica R Mader; Zachary T Resch; Gary R McLean; Jakob H Mikkelsen; Claus Oxvig; Ronald J Marler; Cheryl A Conover Journal: J Endocrinol Date: 2013-09-06 Impact factor: 4.286