AIM: To investigate quality of life (QOL) and the effect of memantine treatment in patients with Lewy body dementias. METHODS: A secondary analysis of a randomized controlled study in 70 patients with Parkinson's disease dementia (PDD) or dementia with Lewy bodies (DLB) over 24 weeks using caregiver-rated QOL-Alzheimer's disease (AD) in domains according to the WHO's classification of health. RESULTS: Baseline QOL shows lower ratings for body functions over environmental factors in DLB/PDD. Treatment with memantine significantly improves life as a whole compared to placebo and improves total QOL, body function and structure. CONCLUSION: This study shows that memantine improves QOL in Lewy body dementias. We also demonstrate important QOL patterns which can be used in clinical practice.
RCT Entities:
AIM: To investigate quality of life (QOL) and the effect of memantine treatment in patients with Lewy body dementias. METHODS: A secondary analysis of a randomized controlled study in 70 patients with Parkinson's disease dementia (PDD) or dementia with Lewy bodies (DLB) over 24 weeks using caregiver-rated QOL-Alzheimer's disease (AD) in domains according to the WHO's classification of health. RESULTS: Baseline QOL shows lower ratings for body functions over environmental factors in DLB/PDD. Treatment with memantine significantly improves life as a whole compared to placebo and improves total QOL, body function and structure. CONCLUSION: This study shows that memantine improves QOL in Lewy body dementias. We also demonstrate important QOL patterns which can be used in clinical practice.
Authors: John-Paul Taylor; Ian G McKeith; David J Burn; Brad F Boeve; Daniel Weintraub; Claire Bamford; Louise M Allan; Alan J Thomas; John T O'Brien Journal: Lancet Neurol Date: 2019-09-10 Impact factor: 44.182
Authors: Samantha K Holden; Claire E Koljack; Lindsay P Prizer; Stefan H Sillau; Janis M Miyasaki; Benzi M Kluger Journal: Parkinsonism Relat Disord Date: 2019-06-23 Impact factor: 4.891
Authors: Laura Brennan; Alexander Pantelyat; John E Duda; James F Morley; Daniel Weintraub; Jayne R Wilkinson; Paul J Moberg Journal: Mov Disord Clin Pract Date: 2015-12-07