Literature DB >> 22122918

Effect of photodynamic therapy and endostatin on human glioma xenografts in nude mice.

Qi Zhan1, Wu Yue, Shaoshan Hu.   

Abstract

The aim of this study was to investigate the effect of endostar (a recombinant human endostatin) and photodynamic therapy (PDT) on gliomas. To establish glioma xenografts, human U251 glioma cells were injected into the brain of nude mice. Mice with MRI-confirmed glioma received hematoporphyrin monomethyl ether (HMME)-mediated PDT, daily injection of endostar or their combination, respectively. After treatment, tumor volume, the expression of HIF-1α, VEGF-A and apoptosis marker, and animal survival were examined. PDT and endostar treatment can prolong survival. Changes in induction of apoptosis, tumor growth and survival were more significant in PDT+endostar group. After PDT, HIF-1α and VEGF-A expressions were markedly increased. After endostar treatment, HIF-1α and VEGF-A expressions were significantly reduced. PDT in combination with endostar can significantly inhibit the growth of glioma xenografts. This approach may represent a promising strategy in the treatment of glioma.
Copyright © 2011 Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 22122918     DOI： 10.1016/j.pdpdt.2011.04.002

Source DB:  PubMed          Journal:  Photodiagnosis Photodyn Ther        ISSN： 1572-1000            Impact factor:   3.631


  8 in total

1.  The inhibitory effects of Endostar combined with chemotherapy on human esophageal squamous cell carcinoma xenograft in mice.

Authors:  Liang Chang; Fengjie Guo; Yalei Lv; Yudong Wang; Bingjie Huo; Long Wang; Wei Liu
Journal:  Mol Biol Rep       Date:  2012-10-11       Impact factor: 2.316

2.  Nanoparticle Delivered VEGF-A siRNA Enhances Photodynamic Therapy for Head and Neck Cancer Treatment.

Authors:  Rumwald Leo G Lecaros; Leaf Huang; Tsai-Chia Lee; Yih-Chih Hsu
Journal:  Mol Ther       Date:  2015-09-16       Impact factor: 11.454

3.  Growth inhibition effect of HMME-mediated PDT on hepatocellular carcinoma HepG2 cells.

Authors:  Lifeng Liu; Yuanjian Song; Limin Ma; Lixin Zang; Lili Tao; Zhiguo Zhang; Jiwu Han
Journal:  Lasers Med Sci       Date:  2014-05-06       Impact factor: 3.161

4.  Inhibition of the HIF-1 Survival Pathway as a Strategy to Augment Photodynamic Therapy Efficacy.

Authors:  Mark J de Keijzer; Daniel J de Klerk; Lianne R de Haan; Robert T van Kooten; Leonardo P Franchi; Lionel M Dias; Tony G Kleijn; Diederick J van Doorn; Michal Heger
Journal:  Methods Mol Biol       Date:  2022

5.  HMME combined with green light-emitting diode irradiation results in efficient apoptosis on human tongue squamous cell carcinoma.

Authors:  Xingqiang Lai; Fen Ning; Xiuwen Xia; Dujuan Wang; Lin Tang; Jiang Hu; Junchao Wu; Jianzhong Liu; Xiaoyuan Li
Journal:  Lasers Med Sci       Date:  2015-07-26       Impact factor: 3.161

6.  Enhanced antitumor efficacy of an oncolytic herpes simplex virus expressing an endostatin-angiostatin fusion gene in human glioblastoma stem cell xenografts.

Authors:  Guobin Zhang; Guishan Jin; Xiutao Nie; Ruifang Mi; Guidong Zhu; William Jia; Fusheng Liu
Journal:  PLoS One       Date:  2014-04-22       Impact factor: 3.240

7.  Hematoporphyrin monomethyl ether-mediated photodynamic therapy selectively kills sarcomas by inducing apoptosis.

Authors:  Hui Zeng; Mengxiong Sun; Chenghao Zhou; Fei Yin; Zhuoying Wang; Yingqi Hua; Zhengdong Cai
Journal:  PLoS One       Date:  2013-10-30       Impact factor: 3.240

8.  Effect of photodynamic therapy combined with torasemide on the expression of matrix metalloproteinase 2 and sodium-potassium-chloride cotransporter 1 in rat peritumoral edema and glioma.

Authors:  B O Li; Chao Meng; Xufeng Zhang; Damin Cong; Xin Gao; Wanlong Gao; Donghui Ju; Shaoshan Hu
Journal:  Oncol Lett       Date:  2016-02-09       Impact factor: 2.967
  8 in total

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