Intensifying treatment of type 2 diabetes mellitus: adding insulin.

Treatment for patients with type 2 diabetes mellitus is typically initiated with a combination of lifestyle modification and oral drugs. This treatment provides sustained glycemic control in some patients, but many others require administration of insulin as their disease progresses and pancreatic β cells are lost. One of the most important points in long-term care for patients with type 2 diabetes is the transition to insulin therapy. Health care professionals must choose the most appropriate insulin preparations for management of patients with type 2 diabetes who cannot achieve treatment goals by using other therapies. These include basal, premixed, and basal-bolus insulin regimens. In addition, there are multiple approaches to initiation of insulin treatment, including addition of basal insulin to oral drugs, switching patients to a premixed insulin formulation, or basal-bolus treatment. The pharmacist can play a key role in the transition to insulin therapy by providing education and assisting in day-to-day management of patients with type 2 diabetes who require insulin for intensification of treatment.