Literature DB >> 22121388

The aging immune system and its relationship with cancer.

Anthony D Foster1, Amogh Sivarapatna, Ronald E Gress.   

Abstract

The incidence of most common cancers increases with age. This occurs in association with, and is possibly caused by a decline in immune function, termed immune senescence. Although the size of the T-cell compartment is quantitatively maintained into older age, several deleterious changes (including significant changes to T-cell subsets) occur over time that significantly impair immunity. This article highlights some of the recent findings regarding the aging immune system, with an emphasis on the T-cell compartment and its role in cancer.

Entities:  

Year:  2011        PMID： 22121388      PMCID： PMC3222953          DOI： 10.2217/ahe.11.56

Source DB:  PubMed          Journal:  Aging health        ISSN： 1745-509X


  92 in total

1.  The aged thymus shows normal recruitment of lymphohematopoietic progenitors but has defects in thymic epithelial cells.

Authors:  Jingang Gui; Xike Zhu; Junichi Dohkan; Lili Cheng; Peter F Barnes; Dong-Ming Su
Journal:  Int Immunol       Date:  2007-09-05       Impact factor: 4.823

Review 2.  Intrinsic versus environmental influences on T-cell responses in aging.

Authors:  Phyllis-Jean Linton; Shaokang P Li; Yu Zhang; Beverly Bautista; Quan Huynh; Tan Trinh
Journal:  Immunol Rev       Date:  2005-06       Impact factor: 12.988

3.  TNF-alpha-induced apoptosis in human naïve and memory CD8+ T cells in aged humans.

Authors:  Sudhir Gupta; Sastry Gollapudi
Journal:  Exp Gerontol       Date:  2005-11-14       Impact factor: 4.032

4.  Late age (85 years or older) peak incidence of bladder cancer.

Authors:  Matthew Schultzel; Sidney L Saltzstein; Tracy M Downs; Suzuho Shimasaki; Catherine Sanders; Georgia Robins Sadler
Journal:  J Urol       Date:  2008-03-04       Impact factor: 7.450

Review 5.  The role of immunity in elderly cancer.

Authors:  Lucia Malaguarnera; Erika Cristaldi; Mariano Malaguarnera
Journal:  Crit Rev Oncol Hematol       Date:  2009-07-04       Impact factor: 6.312

6.  Adaptive immunity maintains occult cancer in an equilibrium state.

Authors:  Catherine M Koebel; William Vermi; Jeremy B Swann; Nadeen Zerafa; Scott J Rodig; Lloyd J Old; Mark J Smyth; Robert D Schreiber
Journal:  Nature       Date:  2007-11-18       Impact factor: 49.962

7.  The inflammatory microenvironment of the aging prostate facilitates cellular proliferation and hypertrophy.

Authors:  L A Begley; S Kasina; J MacDonald; J A Macoska
Journal:  Cytokine       Date:  2008-06-24       Impact factor: 3.861

8.  Interleukin-12 is sufficient to promote antigen-independent interferon-gamma production by CD8 T cells in old mice.

Authors:  Erin K Rottinghaus; Bridget Vesosky; Joanne Turner
Journal:  Immunology       Date:  2009-02-09       Impact factor: 7.397

Review 9.  Immunity and immunization in elderly.

Authors:  Patrice Bourée
Journal:  Pathol Biol (Paris)       Date:  2003-12

10.  Age related changes in T cell mediated immune response and effector memory to Respiratory Syncytial Virus (RSV) in healthy subjects.

Authors:  Maria Grazia Cusi; Barbara Martorelli; Giuseppa Di Genova; Chiara Terrosi; Giuseppe Campoccia; Pierpaolo Correale
Journal:  Immun Ageing       Date:  2010-10-20       Impact factor: 6.400
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  27 in total

1.  Thymus Size and Age-related Thymic Involution: Early Programming, Sexual Dimorphism, Progenitors and Stroma.

Authors:  Jingang Gui; Lisa Maria Mustachio; Dong-Ming Su; Ruth W Craig
Journal:  Aging Dis       Date:  2012-03-14       Impact factor: 6.745

2.  Effects of aging on human leukocytes (part II): immunophenotyping of adaptive immune B and T cell subsets.

Authors:  Ulrik Stervbo; Cecilia Bozzetti; Udo Baron; Karsten Jürchott; Sarah Meier; Julia Nora Mälzer; Mikalai Nienen; Sven Olek; Dominika Rachwalik; Axel Ronald Schulz; Avidan Neumann; Nina Babel; Andreas Grützkau; Andreas Thiel
Journal:  Age (Dordr)       Date:  2015-09-02

3.  Effects of Age and Immune Landscape on Outcome in HER2-Positive Breast Cancer in the NCCTG N9831 (Alliance) and NSABP B-31 (NRG) Trials.

Authors:  Saranya Chumsri; Daniel J Serie; Zhuo Li; Katherine L Pogue-Geile; Aixa E Soyano-Muller; Afshin Mashadi-Hossein; Sarah Warren; Yanyan Lou; Gerardo Colon-Otero; Keith L Knutson; Edith A Perez; Alvaro Moreno-Aspitia; E Aubrey Thompson
Journal:  Clin Cancer Res       Date:  2019-02-26       Impact factor: 12.531

4.  Anti-tumour effects of polysaccharides isolated from Artemisia annua L by inducing cell apoptosis and immunomodulatory anti-hepatoma effects of polysaccharides.

Authors:  Jiayu Chen; Jiaqi Chen; Xintai Wang; Chibo Liu
Journal:  Afr J Tradit Complement Altern Med       Date:  2013-11-02

5.  Haploidentical transplantation using posttransplant cyclophosphamide as GVHD prophylaxis in patients over age 70.

Authors:  Philip H Imus; Hua-Ling Tsai; Leo Luznik; Ephraim J Fuchs; Carol Ann Huff; Douglas E Gladstone; Patrick Lowery; Richard F Ambinder; Ivan M Borrello; Lode J Swinnen; Nina Wagner-Johnston; Christian B Gocke; Syed Abbas Ali; F Javier Bolaños-Meade; Ravi Varadhan; Richard J Jones
Journal:  Blood Adv       Date:  2019-09-10

6.  Thymic Epithelial Cell Support of Thymopoiesis Does Not Require Klotho.

Authors:  Yan Xing; Michelle J Smith; Christine A Goetz; Ron T McElmurry; Sarah L Parker; Dullei Min; Georg A Hollander; Kenneth I Weinberg; Jakub Tolar; Heather E Stefanski; Bruce R Blazar
Journal:  J Immunol       Date:  2018-10-29       Impact factor: 5.422

7.  Age-related tumor growth in mice is related to integrin α 4 in CD8+ T cells.

Authors:  Juhyun Oh; Angela Magnuson; Christophe Benoist; Mikael J Pittet; Ralph Weissleder
Journal:  JCI Insight       Date:  2018-11-02

8.  MicroRNA-195a-5p inhibits mouse medullary thymic epithelial cells proliferation by directly targeting Smad7.

Authors:  Dongguang Guo; Yaqiong Ye; Junjie Qi; Lifeng Xu; Lihua Zhang; Xiaotong Tan; Zhigang Tan; Xiaofang Yu; Yuan Zhang; Yongjiang Ma; Yugu Li
Journal:  Acta Biochim Biophys Sin (Shanghai)       Date:  2016-02-01       Impact factor: 3.848

9.  Abdominal Obesity-Related Disturbance of Insulin Sensitivity Is Associated with CD8+ EMRA Cells in the Elderly.

Authors:  Tim K Boßlau; Paulina Wasserfurth; Britta Krüger; Thomas Reichel; Jana Palmowski; Josefine Nebl; Christopher Weyh; Alexander Schenk; Niklas Joisten; Frank Stahl; Stefanie Thoms; Kristina Gebhardt; Andreas Hahn; Karsten Krüger
Journal:  Cells       Date:  2021-04-23       Impact factor: 6.600

10.  Aging- and Tumor-Mediated Increase in CD8+CD28- T Cells Might Impose a Strong Barrier to Success of Immunotherapy in Glioblastoma.

Authors:  Wei X Huff; Marpe Bam; Jack M Shireman; Jae Hyun Kwon; Leo Song; Sharlé Newman; Aaron A Cohen-Gadol; Scott Shapiro; Tamara Jones; Kelsey Fulton; Sheng Liu; Hiromi Tanaka; Yunlong Liu; Jun Wan; Mahua Dey
Journal:  Immunohorizons       Date:  2021-06-08
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