Literature DB >> 22120501

New sesquiterpenoids from the dried flower buds of Tussilago farfara and their inhibition on NO production in LPS-induced RAW264.7 cells.

Wei Li1, Xin Huang, Xiu-Wei Yang.   

Abstract

Three new sesquiterpenoids, 1α-(3″-ethyl-cis-crotonoyloxy)-8-angeloyloxy-3β,4β-epoxy-bisabola-7(14),10-diene (1), 7β-angeloyloxy-14-hydroxy-notonipetranone (2) and 1α-hydroxy-7β-(4-methylsenecioyloxy)-oplopa-3(14)Z,8(10)-dien-2-one (3) were isolated from ethanolic extract of the dried flower buds of Tussilago farfara L., along with nine known sesquiterpenoids (4-12). All of these compounds were evaluated for their effect on the inhibition of nitric oxide (NO) production induced by lipopolysaccharide in macrophage cell line RAW 264.7 and exhibited inhibitory activity on NO production in a dose-dependent manner. 7β-(4-Methylsenecioyloxy)-oplopa-3(14)E,8(10)-dien-2-one (8) was proved to be the best among these tested sesquiterpenoids with an IC(50) value of 10.80 μM.
Copyright © 2011 Elsevier B.V. All rights reserved.

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Year:  2011        PMID： 22120501     DOI： 10.1016/j.fitote.2011.11.011

Source DB:  PubMed          Journal:  Fitoterapia        ISSN： 0367-326X            Impact factor:   2.882


  7 in total

1.  Effects of Flower Buds Extract of Tussilago farfara on Focal Cerebral Ischemia in Rats and Inflammatory Response in BV2 Microglia.

Authors:  Ji Hye Hwang; Vinoth R Kumar; Seok Yong Kang; Hyo Won Jung; Yong-Ki Park
Journal:  Chin J Integr Med       Date:  2018-08-08       Impact factor: 1.978

2.  A Comparative Analysis of the Anatomy, Phenolic Profile, and Antioxidant Capacity of Tussilago farfara L. Vegetative Organs.

Authors:  Viviane Beatrice Bota; Andreea-Adriana Neamtu; Neli-Kinga Olah; Elisabeta Chișe; Ramona Flavia Burtescu; Flavia Roxana Pripon Furtuna; Alexandru-Sabin Nicula; Carmen Neamtu; Adrian-Marius Maghiar; Lăcrămioara-Carmen Ivănescu; Maria-Magdalena Zamfirache; Endre Mathe; Violeta Turcuș
Journal:  Plants (Basel)       Date:  2022-06-23

3.  Anti-Inflammatory Phenolic Acid Esters from the Roots and Rhizomes of Notopterygium incisium and Their Permeability in the Human Caco-2 Monolayer Cell Model.

Authors:  Xiu-Wen Wu; Wei Wei; Xiu-Wei Yang; You-Bo Zhang; Wei Xu; Yan-Fang Yang; Guo-Yue Zhong; Hong-Ning Liu; Shi-Lin Yang
Journal:  Molecules       Date:  2017-06-04       Impact factor: 4.411

4.  Multi-Target Anti-Alzheimer Activities of Four Prenylated Compounds from Psoralea Fructus.

Authors:  Qing-Xia Xu; Ying Hu; Gui-Yang Li; Wei Xu; Ying-Tao Zhang; Xiu-Wei Yang
Journal:  Molecules       Date:  2018-03-08       Impact factor: 4.411

5.  A Sesquiterpenoid from Farfarae Flos Induces Apoptosis of MDA-MB-231 Human Breast Cancer Cells through Inhibition of JAK-STAT3 Signaling.

Authors:  Hyeri Jang; Hyejin Ko; Kwangho Song; Yeong Shik Kim
Journal:  Biomolecules       Date:  2019-07-13

Review 6.  A review of the ethnobotanical value, phytochemistry, pharmacology, toxicity and quality control of Tussilago farfara L. (coltsfoot).

Authors:  Shujuan Chen; Lin Dong; Hongfeng Quan; Xirong Zhou; Jiahua Ma; Wenxin Xia; Hao Zhou; Xueyan Fu
Journal:  J Ethnopharmacol       Date:  2020-10-16       Impact factor: 4.360

7.  Ethnopharmacological in vitro studies on Austria's folk medicine--an unexplored lore in vitro anti-inflammatory activities of 71 Austrian traditional herbal drugs.

Authors:  Sylvia Vogl; Paolo Picker; Judit Mihaly-Bison; Nanang Fakhrudin; Atanas G Atanasov; Elke H Heiss; Christoph Wawrosch; Gottfried Reznicek; Verena M Dirsch; Johannes Saukel; Brigitte Kopp
Journal:  J Ethnopharmacol       Date:  2013-06-13       Impact factor: 4.360
  7 in total

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