Literature DB >> 22120428

Mode of Action analysis of perfluorooctanoic acid (PFOA) tumorigenicity and Human Relevance.

James E Klaunig1, Barbara A Hocevar2, Lisa M Kamendulis2.   

Abstract

Perfluorooctanoic acid (PFOA) is an environmentally persistent chemical used in the manufacturing of a wide array of industrial and commercial products. PFOA has been shown to induce tumors of the liver, testis and pancreas (tumor triad) in rats following chronic dietary administration. PFOA belongs to a group of compounds that are known to activate the PPARα receptor. The PPARα activation Mode of Action was initially addressed in 2003 [9] and further refined in subsequent reviews [92-94]. In the intervening time, additional information on PFOA effects as well as a further refinement of the Mode of Action framework warrants a re-examination of this compound for its cancer induction Mode of Action. This review will address the rodent (rat) cancer data and cancer Mode of Action of PFOA for tumors of the liver, testes and pancreas.
Copyright © 2011 Elsevier Inc. All rights reserved.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 22120428     DOI： 10.1016/j.reprotox.2011.10.014

Source DB:  PubMed          Journal:  Reprod Toxicol        ISSN： 0890-6238            Impact factor:   3.143


  21 in total

1.  Perfluorooctanoic Acid (PFOA)-induced Liver Lesions in Two Strains of Mice Following Developmental Exposures: PPARα Is Not Required.

Authors:  Adam J Filgo; Erin M Quist; Mark J Hoenerhoff; Amy E Brix; Grace E Kissling; Suzanne E Fenton
Journal:  Toxicol Pathol       Date:  2014-11-14       Impact factor: 1.902

2.  Use of high-throughput in vitro toxicity screening data in cancer hazard evaluations by IARC Monograph Working Groups.

Authors:  Weihsueh A Chiu; Kathryn Z Guyton; Matthew T Martin; David M Reif; Ivan Rusyn
Journal:  ALTEX       Date:  2017-07-24       Impact factor: 6.043

3.  Identification of Biomarkers of Exposure to FTOHs and PAPs in Humans Using a Targeted and Nontargeted Analysis Approach.

Authors:  Sonia Dagnino; Mark J Strynar; Rebecca L McMahen; Christopher S Lau; Carol Ball; Stavros Garantziotis; Thomas F Webster; Michael D McClean; Andrew B Lindstrom
Journal:  Environ Sci Technol       Date:  2016-09-12       Impact factor: 9.028

4.  The role of hepatocyte nuclear factor 4-alpha in perfluorooctanoic acid- and perfluorooctanesulfonic acid-induced hepatocellular dysfunction.

Authors:  Kevin M Beggs; Steven R McGreal; Alex McCarthy; Sumedha Gunewardena; Jed N Lampe; Christoper Lau; Udayan Apte
Journal:  Toxicol Appl Pharmacol       Date:  2016-05-03       Impact factor: 4.219

Review 5.  Perfluorinated Alkyl Substances: Emerging Insights Into Health Risks.

Authors:  Philippe Grandjean; Richard Clapp
Journal:  New Solut       Date:  2015-06-17

6.  Perfluorooctanoic acid enhances colorectal cancer DLD-1 cells invasiveness through activating NF-κB mediated matrix metalloproteinase-2/-9 expression.

Authors:  Chen Miao; Jun Ma; Yajie Zhang; Yimin Chu; Ji Li; Rong Kuai; Saiyu Wang; Haixia Peng
Journal:  Int J Clin Exp Pathol       Date:  2015-09-01

7.  Effects of long-term endocrine disrupting compound exposure on Macaca mulatta embryonic stem cells.

Authors:  Uros Midic; Kailey A Vincent; Catherine A VandeVoort; Keith E Latham
Journal:  Reprod Toxicol       Date:  2016-09-07       Impact factor: 3.143

8.  Effect of acute exposure to PFOA on mouse liver cells in vivo and in vitro.

Authors:  Xinmou Wu; Minqing Liang; Zhao Yang; Min Su; Bin Yang
Journal:  Environ Sci Pollut Res Int       Date:  2017-09-08       Impact factor: 4.223

Review 9.  A critical review of perfluorooctanoate and perfluorooctanesulfonate exposure and immunological health conditions in humans.

Authors:  Ellen T Chang; Hans-Olov Adami; Paolo Boffetta; H James Wedner; Jack S Mandel
Journal:  Crit Rev Toxicol       Date:  2016-01-13       Impact factor: 5.635

10.  Prenatal Exposure to Endocrine-Disrupting Chemicals and Subsequent Brain Structure Changes Revealed by Voxel-Based Morphometry and Generalized Q-Sampling MRI.

Authors:  Chao-Yu Shen; Jun-Cheng Weng; Jeng-Dau Tsai; Pen-Hua Su; Ming-Chih Chou; Shu-Li Wang
Journal:  Int J Environ Res Public Health       Date:  2021-04-30       Impact factor: 3.390
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.