OBJECTIVE: Human papillomavirus (HPV) genotype distribution in invasive cervical cancer (ICC) is critical to guide the introduction and to assess the impact of HPV prophylactic vaccines. This study aims to provide specific information for Spain. METHODS: 1043 histological confirmed ICC cases diagnosed from 1940 to 2007 from six Spanish regions were assembled. HPV DNA detection was performed by SPF(10) broad-spectrum PCR followed by deoxyribonucleic acid enzyme immunoassay and genotyping by reverse hybridization line probe assay (LiPA(25)) (version 1). RESULTS: Of 1043 ICC cases, 904 were HPV DNA positive (adjusted prevalence: 89.1%). The eight most common types, in decreasing order, were HPV 16, 18, 33, 31, 45, 35, 52 and 56, accounting for more than 90% of cases. HPV 16 and 18 contributed to 72.4% of all HPV positive ICC cases. In cervical adenocarcinomas, this contribution increased up to 94%. HPV 16 and 18 relative contributions showed a stable pattern over the 60 year study period. HPV 45, 18 and 16-positive ICC cases presented at younger ages than cases with other HPV types (adjusted mean age: 43.8, 45.2, 52.6 and 57.7 years, respectively). CONCLUSIONS: HPV 16 and 18 accounted together for a 72.4% of positive cases, with no statistically significant changes in their relative contributions over the last decades. In 94% of cervical adenocarcinomas we identified at least one of the two HPV types included in the current vaccines (HPV 16/18). Results suggest a major impact of HPV vaccines on reduction of ICC burden in Spain in the HPV vaccinated cohorts.
OBJECTIVE:Human papillomavirus (HPV) genotype distribution in invasive cervical cancer (ICC) is critical to guide the introduction and to assess the impact of HPV prophylactic vaccines. This study aims to provide specific information for Spain. METHODS: 1043 histological confirmed ICC cases diagnosed from 1940 to 2007 from six Spanish regions were assembled. HPV DNA detection was performed by SPF(10) broad-spectrum PCR followed by deoxyribonucleic acid enzyme immunoassay and genotyping by reverse hybridization line probe assay (LiPA(25)) (version 1). RESULTS: Of 1043 ICC cases, 904 were HPV DNA positive (adjusted prevalence: 89.1%). The eight most common types, in decreasing order, were HPV 16, 18, 33, 31, 45, 35, 52 and 56, accounting for more than 90% of cases. HPV 16 and 18 contributed to 72.4% of all HPV positive ICC cases. In cervical adenocarcinomas, this contribution increased up to 94%. HPV 16 and 18 relative contributions showed a stable pattern over the 60 year study period. HPV 45, 18 and 16-positive ICC cases presented at younger ages than cases with other HPV types (adjusted mean age: 43.8, 45.2, 52.6 and 57.7 years, respectively). CONCLUSIONS:HPV 16 and 18 accounted together for a 72.4% of positive cases, with no statistically significant changes in their relative contributions over the last decades. In 94% of cervical adenocarcinomas we identified at least one of the two HPV types included in the current vaccines (HPV 16/18). Results suggest a major impact of HPV vaccines on reduction of ICC burden in Spain in the HPV vaccinated cohorts.
Authors: Mariano Guardado-Estrada; Eligia Juárez-Torres; Edgar Román-Bassaure; Ingrid Medina-Martinez; Ana Alfaro; Rosa Elba Benuto; Michael Dean; Nicolás Villegas-Sepulveda; Jaime Berumen Journal: PLoS One Date: 2014-10-08 Impact factor: 3.240
Authors: Katsiaryna Holl; Andrzej M Nowakowski; Ned Powell; W Glenn McCluggage; Edyta C Pirog; Sabrina Collas De Souza; Wiebren A Tjalma; Mats Rosenlund; Alison Fiander; Maria Castro Sánchez; Vasileia Damaskou; Elmar A Joura; Benny Kirschner; Robert Koiss; John O'Leary; Wim Quint; Olaf Reich; Aureli Torné; Michael Wells; Lukas Rob; Larisa Kolomiets; Anco Molijn; Alevtina Savicheva; Elena Shipitsyna; Dominique Rosillon; David Jenkins Journal: Int J Cancer Date: 2015-07-14 Impact factor: 7.396
Authors: Claudia Hopenhayn; Amy Christian; Warren Jay Christian; Meg Watson; Elizabeth R Unger; Charles F Lynch; Edward S Peters; Edward J Wilkinson; Youjie Huang; Glenn Copeland; Wendy Cozen; Maria Sibug Saber; Marc T Goodman; Brenda Y Hernandez; Martin Steinau; Christopher Lyu; Thomas T Tucker; Mona Saraiya Journal: J Low Genit Tract Dis Date: 2014-04 Impact factor: 3.842
Authors: M Reyes Oliver Pérez; Victoria Bravo Violeta; Ana Vazquez Del Campo; Cristina Ruiz; Sonia Yáñez Castaño; Laura P Pérez Conde; Jesús S Jiménez López Journal: Infect Agent Cancer Date: 2015-11-16 Impact factor: 2.965