| Literature DB >> 22119988 |
Lei Cui1, Yuezhen Deng, Yefei Rong, Wenhui Lou, Zhengfa Mao, Yuanyuan Feng, Dong Xie, Dayong Jin.
Abstract
Pancreatic cancer is one of the most malignant diseases in the world. Interferon regulator factor 2 (IRF-2), an interferon regulatory factor, has been known to act as an oncogene in distinct types of cancer. In this study, we found that the expression of IRF-2 was up-regulated in primary pancreatic cancer samples and associated with tumor size, differentiation, tumor-node-metastasis stage, and survival of the patients. In pancreatic cancer cells, knockdown on the expression of IRF-2 inhibited cell growth in the liquid culture and on the soft agar. Mechanistically, IRF-2 modulated the growth of pancreatic cancer cells through regulating proliferation and apoptosis effectors, such as cyclin D1 and BAX. Collectively, these results suggest that IRF-2 plays an important role in the tumorigenesis of pancreatic cancer and down-regulation of IRF-2 would be a new treatment target for pancreatic cancer.Entities:
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Year: 2011 PMID： 22119988 DOI： 10.1007/s13277-011-0273-3
Source DB: PubMed Journal: Tumour Biol ISSN： 1010-4283