| Literature DB >> 22119475 |
Victoria E Laing1, Daniel C Brookings, Rachel J Carbery, Jose Gascon Simorte, Martin C Hutchings, Barry J Langham, Martin A Lowe, Rodger A Allen, Joanne R Fetterman, James Turner, Christoph Meier, Jeff Kennedy, Mark Merriman.
Abstract
A number of novel fused thiophene derivatives have been prepared and identified as potent inhibitors of MEK. The SAR data of selected examples and the in vivo profiling of compound 13 h demonstrates the functional activity of this class of compounds in HT-29 PK/PD models.Entities:
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Year: 2011 PMID： 22119475 DOI： 10.1016/j.bmcl.2011.10.105
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823