Publication guidelines for refereeing and reporting on animal use in experimental autoimmune encephalomyelitis.

Experimental autoimmune encephalomyelitis (EAE) is one of the major pre-clinical models of multiple sclerosis. Use of this model has led to some important observations that has benefited human health, but it must also be said that there are many poor-quality studies using EAE that add little to knowledge or understanding. The lack of quality of clinical trials in humans led to the introduction of publication guidelines that aimed to improve the quality and transparency of studies. Therefore, with a view of doing the same, the ARRIVE (Animals in research: Reporting in vivo experiments) guidelines were developed as a checklist of information required for publication of animal studies. Based on the ARRIVE guidelines, we provide guidance on acceptable data handling and indicate the minimal acceptable standard that should be adhered to when reporting and importantly refereeing all publications relating to EAE. This is designed to constructively improve the quality of published work and reduce the futile use of animals in research.