BACKGROUND: Interleukin 17 (IL-17) plays an important role in many autoimmune diseases including neuromyelitis optica (NMO) and multiple sclerosis (MS), which are inflammatory demyelinating diseases of the central nervous system. A large number of non-HLA single nucleotide polymorphisms have been reported to increase the risk of MS. However, their effects on NMO have been less well studied. METHODS: Fifty-two anti-aquaporin 4 antibody-positive NMO patients, 69 anti-aquaporin 4 antibody-negative conventional MS patients, and 131 controls were genotyped for the IL-17A rs2275913 and IL-17F rs763780 single nucleotide polymorphisms by DNA sequencing. RESULTS: Significantly higher frequencies of the rs763780 T allele (p(uncorr)=0.011) and TT genotype (p(uncorr)=0.007, p(corr)=0.042) were observed in NMO patients versus controls. CONCLUSIONS: The rs763780 T allele and TT genotype may increase susceptibility to NMO in the Southern Han Chinese.
BACKGROUND:Interleukin 17 (IL-17) plays an important role in many autoimmune diseases including neuromyelitis optica (NMO) and multiple sclerosis (MS), which are inflammatory demyelinating diseases of the central nervous system. A large number of non-HLA single nucleotide polymorphisms have been reported to increase the risk of MS. However, their effects on NMO have been less well studied. METHODS: Fifty-two anti-aquaporin 4 antibody-positive NMO patients, 69 anti-aquaporin 4 antibody-negative conventional MS patients, and 131 controls were genotyped for the IL-17Ars2275913 and IL-17Frs763780 single nucleotide polymorphisms by DNA sequencing. RESULTS: Significantly higher frequencies of the rs763780 T allele (p(uncorr)=0.011) and TT genotype (p(uncorr)=0.007, p(corr)=0.042) were observed in NMO patients versus controls. CONCLUSIONS: The rs763780 T allele and TT genotype may increase susceptibility to NMO in the Southern Han Chinese.
Authors: Benjamine Arellano; Rehana Hussain; Tresa Zacharias; Jane Yoon; Chella David; Sima Zein; Lawrence Steinman; Thomas Forsthuber; Benjamin M Greenberg; Doris Lambracht-Washington; Alanna M Ritchie; Jeffrey L Bennett; Olaf Stüve Journal: Arch Neurol Date: 2012-09
Authors: Ting Shen; Vivek Gupta; Con Yiannikas; Alexander Klistorner; Stuart L Graham; Yuyi You Journal: Front Neurosci Date: 2019-11-19 Impact factor: 4.677