| Literature DB >> 22118847 |
Euan Smith1, Dorota Gancarz, Allan Rofe, Ivan M Kempson, John Weber, Albert L Juhasz.
Abstract
People are frequently exposed to combinations of contaminants but there is a paucity of data on the effects of mixed contaminants at low doses. This study investigated the influence of cadmium (Cd) on lead (Pb) accumulation in pregnant and non-pregnant mice following exposure to contaminated soil. Exposure to Pb from contaminated soils increased Pb accumulation in both pregnant and non-pregnant mice compared to unexposed control animals (pregnant and non-pregnant). Lead accumulation in the liver and kidneys of exposure pregnant mice (40 ± 15 mg Pb kg(-1)) was significantly higher (P<0.05) than concentrations detected in control pregnant mice (<1 mg Pb kg(-1)). The presence of Cd in contaminated soil had a major effect on the Pb and Fe accumulation in the kidneys and liver, respectively. This study shows that Pb uptake is mediated by the presence of Cd in the co-contaminated soil and demonstrates that further research is required to investigate the influence of co-contaminants on human exposure at sub-chronic concentrations.Entities:
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Year: 2011 PMID： 22118847 DOI： 10.1016/j.jhazmat.2011.11.016
Source DB: PubMed Journal: J Hazard Mater ISSN： 0304-3894 Impact factor: 10.588