BACKGROUND: Much is unclear about the association between attention-deficit/hyperactivity disorder (ADHD) and alcohol use (disorder). Research on this subject is hindered by the role of conduct disorder (CD). We investigate whether (1) childhood ADHD is associated with higher prevalence and earlier onset of alcohol initiation, regular alcohol use and alcohol use disorder (AUD) (2) CD mediates or modifies this association. METHODS: Data were derived from the baseline assessment of the Netherlands Mental Health Survey and Incidence Study-2, a general population study. ADHD and CD were assessed among respondents aged 18-44 (n=3309). ADHD, CD, and alcohol use (disorder) were assessed using the Composite International Diagnostic Interview 3.0. RESULTS: Lifetime prevalence was 2.9% for ADHD, 5.6% for CD, 94.3% for alcohol initiation, 85.7% for regular alcohol use and 19.0% for AUD; mean ages of onset were 6.7, 11.5, 14.8, 16.7 and 19.2 years, respectively. After correction for gender and age, ADHD was associated with a higher prevalence of all three stages of alcohol use, but not with earlier onset of these stages. The association between ADHD and prevalence of AUD was fully explained by a mediating role of CD. CD did not modify the associations between ADHD and prevalence and onset of alcohol use (disorder). CONCLUSIONS: The mediating role of CD in the association between ADHD and AUD suggests a developmental pathway from ADHD to CD and subsequent AUD. Early interventions in children with ADHD may prevent CD and subsequent onset of AUD.
BACKGROUND: Much is unclear about the association between attention-deficit/hyperactivity disorder (ADHD) and alcohol use (disorder). Research on this subject is hindered by the role of conduct disorder (CD). We investigate whether (1) childhood ADHD is associated with higher prevalence and earlier onset of alcohol initiation, regular alcohol use and alcohol use disorder (AUD) (2) CD mediates or modifies this association. METHODS: Data were derived from the baseline assessment of the Netherlands Mental Health Survey and Incidence Study-2, a general population study. ADHD and CD were assessed among respondents aged 18-44 (n=3309). ADHD, CD, and alcohol use (disorder) were assessed using the Composite International Diagnostic Interview 3.0. RESULTS: Lifetime prevalence was 2.9% for ADHD, 5.6% for CD, 94.3% for alcohol initiation, 85.7% for regular alcohol use and 19.0% for AUD; mean ages of onset were 6.7, 11.5, 14.8, 16.7 and 19.2 years, respectively. After correction for gender and age, ADHD was associated with a higher prevalence of all three stages of alcohol use, but not with earlier onset of these stages. The association between ADHD and prevalence of AUD was fully explained by a mediating role of CD. CD did not modify the associations between ADHD and prevalence and onset of alcohol use (disorder). CONCLUSIONS: The mediating role of CD in the association between ADHD and AUD suggests a developmental pathway from ADHD to CD and subsequent AUD. Early interventions in children with ADHD may prevent CD and subsequent onset of AUD.
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Authors: Jukka Savolainen; W Alex Mason; Jonathan D Bolen; Mary B Chmelka; Tuula Hurtig; Hanna Ebeling; Tanja Nordström; Anja Taanila Journal: Crim Behav Ment Health Date: 2014-09-24
Authors: John Fayyad; Nancy A Sampson; Irving Hwang; Tomasz Adamowski; Sergio Aguilar-Gaxiola; Ali Al-Hamzawi; Laura H S G Andrade; Guilherme Borges; Giovanni de Girolamo; Silvia Florescu; Oye Gureje; Josep Maria Haro; Chiyi Hu; Elie G Karam; Sing Lee; Fernando Navarro-Mateu; Siobhan O'Neill; Beth-Ellen Pennell; Marina Piazza; José Posada-Villa; Margreet Ten Have; Yolanda Torres; Miguel Xavier; Alan M Zaslavsky; Ronald C Kessler Journal: Atten Defic Hyperact Disord Date: 2016-11-19
Authors: Maria Paraskevopoulou; Daan van Rooij; Albert Batalla; Roselyne Chauvin; Maartje Luijten; Aart H Schene; Jan K Buitelaar; Arnt F A Schellekens Journal: Neuropsychopharmacology Date: 2020-11-12 Impact factor: 7.853
Authors: C Christ; M Ten Have; R de Graaf; D J F van Schaik; M J Kikkert; J J M Dekker; A T F Beekman Journal: Epidemiol Psychiatr Sci Date: 2019-01-17 Impact factor: 6.892
Authors: Camila Magalhães Silveira; Erica Rosanna Siu; James C Anthony; Luis Paulo Saito; Arthur Guerra de Andrade; Andressa Kutschenko; Maria Carmen Viana; Yuan-Pang Wang; Silvia S Martins; Laura Helena Andrade Journal: PLoS One Date: 2014-10-01 Impact factor: 3.240
Authors: Carolina Hanna Chaim; Geilson Lima Santana; Paula de Vries Albertin; Camila Magalhães Silveira; Erica Rosanna Siu; Maria Carmen Viana; Wang Yuan Pang; Laura Helena Andrade Journal: PLoS One Date: 2021-03-23 Impact factor: 3.240
Authors: Sally I Sharp; Andrew McQuillin; Michael Marks; Stephen P Hunt; S Clare Stanford; Greg J Lydall; Marsha Y Morgan; Philip Asherson; David Curtis; Hugh M D Gurling Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2014-05-09 Impact factor: 3.568
Authors: Kouichi Yoshimasu; William J Barbaresi; Robert C Colligan; Robert G Voigt; Amy L Weaver; Slavica K Katusic Journal: PLoS One Date: 2016-06-13 Impact factor: 3.240