| Literature DB >> 22118658 |
Tae Hee Kim1, Christopher W Mount, Benjamin W Dulken, Jenelyn Ramos, Caroline J Fu, Htet A Khant, Wah Chiu, Wayne R Gombotz, Suzie H Pun.
Abstract
Polymeric micelles formed by the self-assembly of amphiphilic block copolymers can be used to encapsulate hydrophobic drugs for tumor-delivery applications. Filamentous carriers with high aspect ratios offer potential advantages over spherical carriers, including prolonged circulation times. In this work, mixed micelles composed of poly(ethylene oxide)-poly[(R)-3-hydroxybutyrate]-poly(ethylene oxide) (PEO-PHB-PEO) and Pluronic F-127 (PF-127) were used to encapsulate a near-infrared fluorophore. The micelle formulations were assessed for tumor accumulation after tail vein injection to xenograft tumor-bearing mice by noninvasive optical imaging. The mixed micelle formulation that facilitated the highest tumor accumulation was shown by cryo-electron microscopy to be filamentous in structure compared to spherical structures of pure PF-127 micelles. In addition, increased dye loading efficiency and dye stability were attained in this mixed micelle formulation compared to pure PEO-PHB-PEO micelles. Therefore, the optimized PEO-PHB-PEO/PF-127 mixed micelle formulation offers advantages for cancer delivery over micelles formed from the individual copolymer components.Entities:
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Year: 2011 PMID： 22118658 PMCID： PMC3256244 DOI： 10.1021/mp200381c
Source DB: PubMed Journal: Mol Pharm ISSN： 1543-8384 Impact factor: 4.939