OBJECTIVE: To assess adherence to isoniazid preventive therapy (IPT) in children exposed to adult pulmonary tuberculosis (TB) at home. METHODS: Children were enrolled on IPT if they were aged ≤ 5 years or 5-15 years and presented a tuberculin skin test induration of ≥ 10 mm. Children were included from the demographic surveillance system of the Bandim Health Project in Bissau, Guinea-Bissau. The main outcome measures were adherence, completion rates and side effects during 9 months of IPT. The main outcome was 6 consecutive months of at least 80% adherence. RESULTS: A total of 2631 children were identified as contacts of adult TB cases. Among the children identified, 1895 (72%) were evaluated for eligibility for IPT, and 820 were enrolled in the study: 609 were aged ≤ 5 years and 211 aged 5-15 years. A total of 79% of the prescribed doses were taken, with 65% of the children taking > 80% of their doses. In all, 51% completed more than 6 consecutive months of IPT. CONCLUSION: Overall adherence to IPT was better than previously reported from TB-endemic areas, with 76% of the children completing at least 6 months of treatment, with more than 80% adherence.
OBJECTIVE: To assess adherence to isoniazid preventive therapy (IPT) in children exposed to adult pulmonary tuberculosis (TB) at home. METHODS:Children were enrolled on IPT if they were aged ≤ 5 years or 5-15 years and presented a tuberculin skin test induration of ≥ 10 mm. Children were included from the demographic surveillance system of the Bandim Health Project in Bissau, Guinea-Bissau. The main outcome measures were adherence, completion rates and side effects during 9 months of IPT. The main outcome was 6 consecutive months of at least 80% adherence. RESULTS: A total of 2631 children were identified as contacts of adult TB cases. Among the children identified, 1895 (72%) were evaluated for eligibility for IPT, and 820 were enrolled in the study: 609 were aged ≤ 5 years and 211 aged 5-15 years. A total of 79% of the prescribed doses were taken, with 65% of the children taking > 80% of their doses. In all, 51% completed more than 6 consecutive months of IPT. CONCLUSION: Overall adherence to IPT was better than previously reported from TB-endemic areas, with 76% of the children completing at least 6 months of treatment, with more than 80% adherence.
Authors: Merrin E Rutherford; Rovina Ruslami; Melissa Anselmo; Bachti Alisjahbana; Neti Yulianti; Hedy Sampurno; Reinout van Crevel; Philip C Hill Journal: Bull World Health Organ Date: 2013-09-10 Impact factor: 9.408
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Authors: U Egere; A Sillah; T Togun; S Kandeh; F Cole; A Jallow; A Able-Thomas; M Hoelscher; N Heinrich; P C Hill; B Kampmann Journal: Public Health Action Date: 2016-12-21
Authors: M Tolofoudie; A Somboro; B Diarra; Y S Sarro; H B Drame; A C G Togo; M Sanogo; A Dembele; T Togun; E Nkereuwem; B Baya; B Konate; U Egere; M Traore; M Maiga; K Saliba-Shaw; B Kampmann; S Diallo; S Doumbia; M Sylla Journal: Public Health Action Date: 2021-12-21
Authors: Victor Francisco Gomes; Andreas Andersen; Grethe Lemvik; Christian Wejse; Ines Oliveira; Fina J Vieira; Luis José Carlos; Cesaltina da Silva Vieira; Peter Aaby; Per Gustafson Journal: BMJ Open Date: 2013-03-26 Impact factor: 2.692
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