BACKGROUND: Thalamic volume deficits are associated with psychosis but it is unclear whether the volume reduction is uniformly distributed or whether it is more severe in particular thalamic regions. AIMS: To quantify whole and regional thalamic volume in males with early-onset psychosis and healthy male controls. METHOD: Brain scans were obtained for 80 adolescents: 46 individuals with early-onset psychosis with a duration of positive symptoms less than 6 months and 34 healthy controls. All participants were younger than 19 years. Total thalamic volumes were assessed using FreeSurfer and FSL-FIRST, group comparisons of regional thalamic volumes were studied with a surface-based approach. RESULTS: Total thalamic volume was smaller in participants with early-onset psychosis relative to controls. Regional thalamic volume reduction was most significant in the right anterior mediodorsal area and pulvinar. CONCLUSIONS: In males with minimally treated early-onset psychosis, thalamic volume deficits may be most pronounced in the anterior mediodorsal and posterior pulvinar regions, adding strength to findings from post-mortem studies in adults with psychosis.
BACKGROUND:Thalamic volume deficits are associated with psychosis but it is unclear whether the volume reduction is uniformly distributed or whether it is more severe in particular thalamic regions. AIMS: To quantify whole and regional thalamic volume in males with early-onset psychosis and healthy male controls. METHOD: Brain scans were obtained for 80 adolescents: 46 individuals with early-onset psychosis with a duration of positive symptoms less than 6 months and 34 healthy controls. All participants were younger than 19 years. Total thalamic volumes were assessed using FreeSurfer and FSL-FIRST, group comparisons of regional thalamic volumes were studied with a surface-based approach. RESULTS: Total thalamic volume was smaller in participants with early-onset psychosis relative to controls. Regional thalamic volume reduction was most significant in the right anterior mediodorsal area and pulvinar. CONCLUSIONS: In males with minimally treated early-onset psychosis, thalamic volume deficits may be most pronounced in the anterior mediodorsal and posterior pulvinar regions, adding strength to findings from post-mortem studies in adults with psychosis.
Authors: Laura Pina-Camacho; Ángel Del Rey-Mejías; Joost Janssen; Miquel Bioque; Ana González-Pinto; Celso Arango; Antonio Lobo; Salvador Sarró; Manuel Desco; Julio Sanjuan; Maria Lacalle-Aurioles; Manuel J Cuesta; Jerónimo Saiz-Ruiz; Miguel Bernardo; Mara Parellada Journal: Schizophr Bull Date: 2015-09-14 Impact factor: 9.306
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Authors: Tiril P Gurholt; Vera Lonning; Stener Nerland; Kjetil N Jørgensen; Unn K Haukvik; Clara Alloza; Celso Arango; Claudia Barth; Carrie E Bearden; Michael Berk; Hannes Bohman; Orwa Dandash; Covadonga M Díaz-Caneja; Carl T Edbom; Theo G M van Erp; Anne-Kathrin J Fett; Sophia Frangou; Benjamin I Goldstein; Anahit Grigorian; Neda Jahanshad; Anthony C James; Joost Janssen; Cecilie Johannessen; Katherine H Karlsgodt; Matthew J Kempton; Peter Kochunov; Lydia Krabbendam; Marinos Kyriakopoulos; Mathias Lundberg; Bradley J MacIntosh; Bjørn Rishovd Rund; Runar E Smelror; Alysha Sultan; Christian K Tamnes; Sophia I Thomopoulos; Ariana Vajdi; Kirsten Wedervang-Resell; Anne M Myhre; Ole A Andreassen; Paul M Thompson; Ingrid Agartz Journal: Hum Brain Mapp Date: 2020-10-05 Impact factor: 5.399