Gia Oh1, Keith K Lau. 1. Division of Nephrology, Department of Pediatrics, Stanford University, 300 Pasteur Drive, G306 MC 5208 Stanford, Palo Alto, CA 94305, USA. gjoh@stanford.edu
Abstract
PURPOSE: Hemolytic uremic syndrome (HUS) is a frequent cause of acute kidney injury in children. The aim of this study is to describe our experience at a Northern California center. METHODS: Medical records of children suffered from HUS (08/99 to 03/09) at University of California Davis Medical Center were reviewed. RESULTS: Forty-six children (70% girls) were studied, and their median age was 3.5 years. Diarrhea was a presenting symptom in 42 subjects (91%), and hematochezia was present in 31 children (67%). Escherichia coli 0157:H7 was isolated in 20 patients (44%). Thirteen subjects (28%) underwent dialysis for a median of 7 days during their hospitalization. Follow-up was achieved in 36 patients (78.3%) for a median of 16 months. One patient required angiotensin-converting enzyme (ACE) inhibitor for proteinuria but none was on dialysis. CONCLUSIONS: In our cohort in children with HUS in a single Californian center, long-term complications were uncommon during a median follow-up time of 16 months.
PURPOSE:Hemolytic uremic syndrome (HUS) is a frequent cause of acute kidney injury in children. The aim of this study is to describe our experience at a Northern California center. METHODS: Medical records of children suffered from HUS (08/99 to 03/09) at University of California Davis Medical Center were reviewed. RESULTS: Forty-six children (70% girls) were studied, and their median age was 3.5 years. Diarrhea was a presenting symptom in 42 subjects (91%), and hematochezia was present in 31 children (67%). Escherichia coli 0157:H7 was isolated in 20 patients (44%). Thirteen subjects (28%) underwent dialysis for a median of 7 days during their hospitalization. Follow-up was achieved in 36 patients (78.3%) for a median of 16 months. One patient required angiotensin-converting enzyme (ACE) inhibitor for proteinuria but none was on dialysis. CONCLUSIONS: In our cohort in children with HUS in a single Californian center, long-term complications were uncommon during a median follow-up time of 16 months.
Authors: Ronald J Hogg; Susan Furth; Kevin V Lemley; Ronald Portman; George J Schwartz; Josef Coresh; Ethan Balk; Joseph Lau; Adeera Levin; Annamaria T Kausz; Garabed Eknoyan; Andrew S Levey Journal: Pediatrics Date: 2003-06 Impact factor: 7.124