Literature DB >> 22115498

Upregulation of Ugt1a genes in placentas and fetal livers in a murine model of assisted reproduction.

A C Collier1, K A Milam, L R A Rougée, A Sugawara, Y Yamauchi, M A Ward.   

Abstract

Genes from Ugt1a family in placenta and fetal liver are responsible for hormone, nutrient and chemical balance during pregnancy. Assisted reproduction technologies (ART) i.e. intracytoplasmic sperm injection (ICSI) and in vitro fertilization (IVF) alter steroid homeostasis in pregnancy through increased glucuronidation. Here we show that ART (particularly ICSI) upregulates Ugt1a1, 1a2, 1a6 and 1a9 expression in murine placentas and fetal livers with higher mRNA related to lower progesterone (1a1) and cholesterol (1a2, 1a6) in placentas. Greater steroid clearance in ART through transcriptional upregulation of Ugt1a in the placental-fetal unit may decrease the availability of essential molecules, mediating negative reproductive outcomes.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 22115498      PMCID： PMC3249018          DOI： 10.1016/j.placenta.2011.11.002

Source DB:  PubMed          Journal:  Placenta        ISSN： 0143-4004            Impact factor:   3.481


  19 in total

1.  A new mathematical model for relative quantification in real-time RT-PCR.

Authors:  M W Pfaffl
Journal:  Nucleic Acids Res       Date:  2001-05-01       Impact factor: 16.971

2.  Placental inflammation and oxidative stress in the mouse model of assisted reproduction.

Authors:  J M Raunig; Y Yamauchi; M A Ward; A C Collier
Journal:  Placenta       Date:  2011-09-01       Impact factor: 3.481

3.  Developmental aspects of human hepatic drug glucuronidation in young children and adults.

Authors:  C P Strassburg; A Strassburg; S Kneip; A Barut; R H Tukey; B Rodeck; M P Manns
Journal:  Gut       Date:  2002-02       Impact factor: 23.059

4.  Assisted reproduction technologies alter steroid delivery to the mouse fetus during pregnancy.

Authors:  Jefferey M Raunig; Yasuhiro Yamauchi; Monika A Ward; Abby C Collier
Journal:  J Steroid Biochem Mol Biol       Date:  2010-12-28       Impact factor: 4.292

5.  UDP-glucuronosyltransferase activity, expression and cellular localization in human placenta at term.

Authors:  Abby C Collier; Natalie A Ganley; Malcolm D Tingle; Marion Blumenstein; Keith W Marvin; James W Paxton; Murray D Mitchell; Jeffrey A Keelan
Journal:  Biochem Pharmacol       Date:  2002-02-01       Impact factor: 5.858

6.  Hepatic expression of the UGT1A9 gene is governed by hepatocyte nuclear factor 4alpha.

Authors:  Olivier Barbier; Hugo Girard; Yusuke Inoue; Hélène Duez; Lyne Villeneuve; Akihide Kamiya; Jean-Charles Fruchart; Chantal Guillemette; Frank J Gonzalez; Bart Staels
Journal:  Mol Pharmacol       Date:  2004-10-06       Impact factor: 4.436

7.  Live offspring from mice lacking the Y chromosome long arm gene complement.

Authors:  Yasuhiro Yamauchi; Jonathan M Riel; Samantha J Wong; Obah A Ojarikre; Paul S Burgoyne; Monika A Ward
Journal:  Biol Reprod       Date:  2009-05-06       Impact factor: 4.285

8.  Metabolizing enzyme localization and activities in the first trimester human placenta: the effect of maternal and gestational age, smoking and alcohol consumption.

Authors:  Abby C Collier; Malcolm D Tingle; James W Paxton; Murray D Mitchell; Jeffrey A Keelan
Journal:  Hum Reprod       Date:  2002-10       Impact factor: 6.918

9.  Induction of UDPglucose dehydrogenase during development, organ culture, and exposure to phenobarbital. Its relation to levels of UDPglucuronic acid and overall glucuronidation in chicken and mouse.

Authors:  J Fyffe; G J Dutton
Journal:  Biochim Biophys Acta       Date:  1975-11-10

10.  Expression of UDP-glucuronosyltransferase 1A4 in human placenta at term.

Authors:  Arne Reimers; Lene Østby; Ina Stuen; Eirik Sundby
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2010-12-30       Impact factor: 2.441
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  5 in total

1.  Single blastomere removal from murine embryos is associated with activation of matrix metalloproteinases and Janus kinase/signal transducers and activators of transcription pathways of placental inflammation.

Authors:  Brittany L M Sato; Atsushi Sugawara; Monika A Ward; Abby C Collier
Journal:  Mol Hum Reprod       Date:  2014-09-01       Impact factor: 4.025

2.  P-gp/ABCB1 exerts differential impacts on brain and fetal exposure to norbuprenorphine.

Authors:  Michael Z Liao; Chunying Gao; Laura M Shireman; Brian Phillips; Linda J Risler; Naveen K Neradugomma; Prachi Choudhari; Bhagwat Prasad; Danny D Shen; Qingcheng Mao
Journal:  Pharmacol Res       Date:  2017-01-19       Impact factor: 7.658

3.  Placental profiling of UGT1A enzyme expression and activity and interactions with preeclampsia at term.

Authors:  Abby C Collier; Audrey D Thévenon; William Goh; Mark Hiraoka; Claire E Kendal-Wright
Journal:  Eur J Drug Metab Pharmacokinet       Date:  2014-12-03       Impact factor: 2.441

4.  UDP-glucuronosyltransferase 1a enzymes are present and active in the mouse blastocyst.

Authors:  Abby C Collier; Yasuhiro Yamauchi; Brittany L M Sato; Luc R A Rougée; Monika A Ward
Journal:  Drug Metab Dispos       Date:  2014-09-08       Impact factor: 3.922

5.  Endocrine Disrupting Effects of Triclosan on the Placenta in Pregnant Rats.

Authors:  Yixing Feng; Pin Zhang; Zhaobin Zhang; Jiachen Shi; Zhihao Jiao; Bing Shao
Journal:  PLoS One       Date:  2016-05-05       Impact factor: 3.240
  5 in total

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