Literature DB >> 22114055

Ripoptosome: a novel IAP-regulated cell death-signalling platform.

Gergely Imre1, Sarit Larisch, Krishnaraj Rajalingam.   

Abstract

Recent studies have revealed that cell death stimuli can trigger programmed necrosis, necroptosis. Receptor-interacting serine-threonine kinase family RIP plays a crucial role in regulating the switch between apoptosis and necroptosis. Two studies now describe a novel RIP1 containing ~2 MDa 'Ripoptosome' complex assembled in the cytosol to mediate both apoptosis and necroptosis in response to genotoxic stress and TLR3 stimulation. Intriguingly, cIAPs and XIAP function as endogenous inhibitors of Ripoptosome by direct ubiquitination of its components.

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Year:  2011        PMID： 22114055     DOI： 10.1093/jmcb/mjr034

Source DB:  PubMed          Journal:  J Mol Cell Biol        ISSN： 1759-4685            Impact factor:   6.216


  20 in total

1.  E3 ubiquitin ligase HOIP attenuates apoptotic cell death induced by cisplatin.

Authors:  Craig MacKay; Eilís Carroll; Adel F M Ibrahim; Amit Garg; Gareth J Inman; Ronald T Hay; Arno F Alpi
Journal:  Cancer Res       Date:  2014-03-31       Impact factor: 12.701

Review 2.  Rational combination strategies to enhance venetoclax activity and overcome resistance in hematologic malignancies.

Authors:  Steven Grant
Journal:  Leuk Lymphoma       Date:  2017-08-24

3.  Overexpression of the X-Linked Inhibitor of Apoptosis Protects Against Retinal Degeneration in a Feline Model of Retinal Detachment.

Authors:  Sarah J Wassmer; Brian C Leonard; Stuart G Coupland; Adam N Baker; John Hamilton; William W Hauswirth; Catherine Tsilfidis
Journal:  Hum Gene Ther       Date:  2017-03-23       Impact factor: 5.695

4.  Bacterium-generated nitric oxide hijacks host tumor necrosis factor alpha signaling and modulates the host cell cycle in vitro.

Authors:  Brian Mocca; Wei Wang
Journal:  J Bacteriol       Date:  2012-05-25       Impact factor: 3.490

5.  Intestinal barrier disruption as a cause of mortality in combined radiation and burn injury.

Authors:  Stewart R Carter; Anita Zahs; Jessica L Palmer; Lu Wang; Luis Ramirez; Richard L Gamelli; Elizabeth J Kovacs
Journal:  Shock       Date:  2013-10       Impact factor: 3.454

Review 6.  Caspase control: protagonists of cancer cell apoptosis.

Authors:  M V Fiandalo; N Kyprianou
Journal:  Exp Oncol       Date:  2012-10

7.  A JNK-mediated autophagy pathway that triggers c-IAP degradation and necroptosis for anticancer chemotherapy.

Authors:  W He; Q Wang; B Srinivasan; J Xu; M T Padilla; Z Li; X Wang; Y Liu; X Gou; H-M Shen; C Xing; Y Lin
Journal:  Oncogene       Date:  2013-07-08       Impact factor: 9.867

8.  Protective effects of necrostatin-1 against concanavalin A-induced acute hepatic injury in mice.

Authors:  Yingqun Zhou; Weiqi Dai; Chunlei Lin; Fan Wang; Lei He; Miao Shen; Ping Chen; Chenfen Wang; Jie Lu; Ling Xu; Xuanfu Xu; Chuanyong Guo
Journal:  Mediators Inflamm       Date:  2013-10-01       Impact factor: 4.711

9.  Toll-like receptor 3 in Epstein-Barr virus-associated nasopharyngeal carcinomas: consistent expression and cytotoxic effects of its synthetic ligand poly(A:U) combined to a Smac-mimetic.

Authors:  Benjamin Vérillaud; Mélanie Gressette; Yannis Morel; Carine Paturel; Philippe Herman; Kwok Wai Lo; Sai Wah Tsao; Michel Wassef; Anne-Sophie Jimenez-Pailhes; Pierre Busson
Journal:  Infect Agent Cancer       Date:  2012-12-03       Impact factor: 2.965

10.  Staurosporine induces necroptotic cell death under caspase-compromised conditions in U937 cells.

Authors:  Zsuzsanna A Dunai; Gergely Imre; Gabor Barna; Tamas Korcsmaros; Istvan Petak; Pal I Bauer; Rudolf Mihalik
Journal:  PLoS One       Date:  2012-07-31       Impact factor: 3.240
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