Literature DB >> 22113941

Creation of a lipase highly selective for trans fatty acids by protein engineering.

Henrike B Brundiek1, Andrew S Evitt, Robert Kourist, Uwe T Bornscheuer.   

Abstract

Sorting out: Protein engineering of lipase CAL-A led to the discovery of mutants with excellent chemoselectivity for the removal of trans and saturated fatty acids from partially hydrogenated vegetable oil. These fatty acids, identified as a major risk factor for human health, can now be removed by enzyme catalysis.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2011        PMID： 22113941     DOI： 10.1002/anie.201106126

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  9 in total

Review 1.  Recombinant Lipases and Phospholipases and Their Use as Biocatalysts for Industrial Applications.

Authors:  Grazia M Borrelli; Daniela Trono
Journal:  Int J Mol Sci       Date:  2015-09-01       Impact factor: 5.923

2.  Biocatalytic potential of lipase from Staphylococcus sp. MS1 for transesterification of jatropha oil into fatty acid methyl esters.

Authors:  Monika Sharma; Shelley Sardul Singh; Pratibha Maan; Rohit Sharma
Journal:  World J Microbiol Biotechnol       Date:  2014-08-13       Impact factor: 3.312

Review 3.  Lipase improvement: goals and strategies.

Authors:  Arnau Bassegoda; Silvia Cesarini; Pilar Diaz
Journal:  Comput Struct Biotechnol J       Date:  2012-10-15       Impact factor: 7.271

4.  Enzyme engineering: A synthetic biology approach for more effective library generation and automated high-throughput screening.

Authors:  Daniela Quaglia; Maximilian C C J C Ebert; Paul F Mugford; Joelle N Pelletier
Journal:  PLoS One       Date:  2017-02-08       Impact factor: 3.240

5.  Alteration of Chain Length Selectivity of Candida antarctica Lipase A by Semi-Rational Design for the Enrichment of Erucic and Gondoic Fatty Acids.

Authors:  Katja Zorn; Isabel Oroz-Guinea; Henrike Brundiek; Mark Dörr; Uwe T Bornscheuer
Journal:  Adv Synth Catal       Date:  2018-09-26       Impact factor: 5.837

6.  Substrate structure and computation guided engineering of a lipase for omega-3 fatty acid selectivity.

Authors:  Tushar Ranjan Moharana; Nalam Madhusudhana Rao
Journal:  PLoS One       Date:  2020-04-09       Impact factor: 3.240

Review 7.  Microbial Lipases and Their Potential in the Production of Pharmaceutical Building Blocks.

Authors:  César A Godoy; Juan S Pardo-Tamayo; Oveimar Barbosa
Journal:  Int J Mol Sci       Date:  2022-09-01       Impact factor: 6.208

8.  Assembly of lipase and P450 fatty acid decarboxylase to constitute a novel biosynthetic pathway for production of 1-alkenes from renewable triacylglycerols and oils.

Authors:  Jinyong Yan; Yi Liu; Cong Wang; Bingnan Han; Shengying Li
Journal:  Biotechnol Biofuels       Date:  2015-02-26       Impact factor: 6.040

9.  Holistic engineering of Cal-A lipase chain-length selectivity identifies triglyceride binding hot-spot.

Authors:  Daniela Quaglia; Lorea Alejaldre; Sara Ouadhi; Olivier Rousseau; Joelle N Pelletier
Journal:  PLoS One       Date:  2019-01-14       Impact factor: 3.240
  9 in total

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