Literature DB >> 22113923

Supramolecular host-guest interaction for labeling and detection of cellular biomarkers.

Sarit S Agasti1, Monty Liong, Carlos Tassa, Hyun Jung Chung, Stanley Y Shaw, Hakho Lee, Ralph Weissleder.   

Abstract

Be my guest: A supramolecular host-guest interaction is utilized for highly efficient bioorthogonal labeling of cellular targets. Antibodies labeled with a cyclodextrin host molecule bind to adamantane-labeled magnetofluorescent nanoparticles (see picture) and provide an amplifiable strategy for biomarker detection that can be adapted to different diagnostic techniques such as molecular profiling or magnetic cell sorting.
Copyright © 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

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Year:  2011        PMID： 22113923      PMCID： PMC3309171          DOI： 10.1002/anie.201105670

Source DB:  PubMed          Journal:  Angew Chem Int Ed Engl        ISSN： 1433-7851            Impact factor:   15.336


  36 in total

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5.  Labeling of immune cells for in vivo imaging using magnetofluorescent nanoparticles.

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2.  Orthogonal amplification of nanoparticles for improved diagnostic sensing.

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Review 6.  Microchip-based detection of magnetically labeled cancer biomarkers.

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7.  Pretargeted Positron Emission Tomography Imaging That Employs Supramolecular Nanoparticles with in Vivo Bioorthogonal Chemistry.

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Review 8.  Magnetic sensing technology for molecular analyses.

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10.  Comparison of select cancer biomarkers in human circulating and bulk tumor cells using magnetic nanoparticles and a miniaturized micro-NMR system.

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