Literature DB >> 2211364

Chemical and biological properties of rubiginone, a complex of new antibiotics with vincristine-cytotoxicity potentiating activity.

M Oka1, H Kamei, Y Hamagishi, K Tomita, T Miyaki, M Konishi, T Oki.   

Abstract

A novel complex of isotetracenone (angucyclinone) group antibiotics was discovered from the cultured broth of Streptomyces griseorubiginosus No. Q144-2. The antibiotic consisted of six related factors, designated rubiginones A1, A2, B1, B2, C1 and C2. They significantly potentiated cytotoxicity of vincristine (VCR) against VCR-resistant P388 leukemia and Moser cells.

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Year:  1990        PMID： 2211364     DOI： 10.7164/antibiotics.43.967

Source DB:  PubMed          Journal:  J Antibiot (Tokyo)        ISSN： 0021-8820            Impact factor:   2.649


  4 in total

1.  Aminopyrimidoisoquinolinequinone (APIQ) redox cycling is potentiated by ascorbate and induces oxidative stress leading to necrotic-like cancer cell death.

Authors:  David R Vásquez; Julien Verrax; Jaime A Valderrama; Pedro Buc Calderon
Journal:  Invest New Drugs       Date:  2011-04-05       Impact factor: 3.850

2.  Moromycins A and B, isolation and structure elucidation of C-glycosylangucycline-type antibiotics from Streptomyces sp. KY002.

Authors:  Mohamed S Abdelfattah; Madan Kumar Kharel; John Andrew Hitron; Irfan Baig; Jürgen Rohr
Journal:  J Nat Prod       Date:  2008-07-31       Impact factor: 4.050

3.  (-)-Shikimic Acid as a Chiral Building Block for the Synthesis of New Cytotoxic 6-Aza-Analogues of Angucyclinones.

Authors:  Natalia Quiñones; Santiago Hernández; Luis Espinoza Catalán; Joan Villena; Ivan Brito; Alan R Cabrera; Cristian O Salas; Mauricio A Cuellar
Journal:  Molecules       Date:  2018-06-12       Impact factor: 4.411

4.  Genome mining of novel rubiginones from Streptomyces sp. CB02414 and characterization of the post-PKS modification steps in rubiginone biosynthesis.

Authors:  Jingyan Zhang; Ying Sun; Yeji Wang; Xin Chen; Lu Xue; Jingjing Zhang; Xiangcheng Zhu; Yanwen Duan; Xiaohui Yan
Journal:  Microb Cell Fact       Date:  2021-10-02       Impact factor: 5.328
  4 in total

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