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Literature DB >> 2211359

Janthinocins A, B and C, novel peptide lactone antibiotics produced by Janthinobacterium lividum. I. Taxonomy, fermentation, isolation, physico-chemical and biological characterization.

J O'Sullivan¹, J McCullough, J H Johnson, D P Bonner, J C Clark, L Dean, W H Trejo.

Abstract

Janthinocins A, B and C are novel antibacterial agents produced by Janthinobacterium lividum. They were isolated from fermentation broths and characterized by UV, IR, NMR and mass spectroscopy. They are cyclic decapeptide lactones with marked activity against aerobic and anaerobic Gram-positive bacteria and are 2 to 4 times more potent in vitro than vancomycin. Janthinocins A and B were also found to be effective in a Staphylococcus aureus systemic infection in mice.

Entities: Chemical Disease Species

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Year: 1990 PMID： 2211359 DOI： 10.7164/antibiotics.43.913

Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649

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Cited

10 in total

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Janthinocins A, B and C, novel peptide lactone antibiotics produced by Janthinobacterium lividum. I. Taxonomy, fermentation, isolation, physico-chemical and biological characterization.

1. Isolation and phylogenetic classification of culturable psychrophilic prokaryotes from the Collins glacier in the Antarctica.

2. Violacein, an indole-derived purple-colored natural pigment produced by Janthinobacterium lividum, inhibits the growth of head and neck carcinoma cell lines both in vitro and in vivo.

3. Symbiotic bacteria associated with puffer fish Gastrophysus spadiceus and evaluation of their antimicrobial activities.

4. Characterization of intestinal bacteria in wild and domesticated adult black tiger shrimp (Penaeus monodon).

Review 5. α,β-Dehydroamino acids in naturally occurring peptides.

Review 6. Novel Biocontrol Methods for Listeria monocytogenes Biofilms in Food Production Facilities.

7. Isolation of Janthinobacterium lividum from early onset neonatal sepsis patients in Malaysia.

Review 8. Biotechnological Activities and Applications of Bacterial Pigments Violacein and Prodigiosin.

9. Draft genome sequence of Janthinobacterium lividum strain MTR reveals its mechanism of capnophilic behavior.

10. The Anopheles coluzzii microbiome and its interaction with the intracellular parasite Wolbachia.