Literature DB >> 22113586

Synthesis of manzacidin A and C: efficient construction of quaternary carbon stereocenters bearing nitrogen substituents.

Yoshiyasu Ichikawa1, Ken Okumura, Yasunori Matsuda, Tomoyuki Hasegawa, Mitsuhiro Nakamura, Aya Fujimoto, Toshiya Masuda, Keiji Nakano, Hiyoshizo Kotsuki.   

Abstract

An efficient synthetic method for stereoselective construction of asymmetric quaternary carbon stereocenters, bearing nitrogen in the form of Boc-protected allyl amines, has been developed. This methodology is employed in the synthesis of marine alkaloids, manzacidin A and C.

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Year:  2011        PMID: 22113586     DOI: 10.1039/c1ob06559a

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN: 1477-0520            Impact factor:   3.876


  2 in total

Review 1.  Enzymatic CH functionalizations for natural product synthesis.

Authors:  Fuzhuo Li; Xiao Zhang; Hans Renata
Journal:  Curr Opin Chem Biol       Date:  2018-09-27       Impact factor: 8.822

2.  Modular synthesis of the pyrimidine core of the manzacidins by divergent Tsuji-Trost coupling.

Authors:  Sebastian Bretzke; Stephan Scheeff; Felicitas Vollmeyer; Friederike Eberhagen; Frank Rominger; Dirk Menche
Journal:  Beilstein J Org Chem       Date:  2016-06-02       Impact factor: 2.883

  2 in total

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