Literature DB >> 22113294

Affinity purification of MLL3/MLL4 histone H3K4 methyltransferase complex.

Young-Wook Cho1, Sunhwa Hong, Kai Ge.   

Abstract

Methylation on histone H3 lysine 4 (H3K4) correlates with actively transcribed genes. In mammalian cells, there exist multiple Set1-like histone H3K4 methyltransferase complexes, which have overlapping but distinct subunit compositions. Developing methods to isolate each of these histone H3K4 methyltransferase complexes would help understand the molecular mechanisms by which histone H3K4 methylation regulates mammalian gene expression. In this chapter, we provide a one-step affinity purification protocol on isolation of the MLL3/MLL4 histone H3K4 methyltransferase complex using FLAG-tagged PA1, a unique subunit of the MLL3/MLL4 complex.

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Year:  2012        PMID： 22113294      PMCID： PMC3467094          DOI： 10.1007/978-1-61779-376-9_30

Source DB:  PubMed          Journal:  Methods Mol Biol        ISSN： 1064-3745


  17 in total

1.  Knockdown of ALR (MLL2) reveals ALR target genes and leads to alterations in cell adhesion and growth.

Authors:  Irina Issaeva; Yulia Zonis; Tanya Rozovskaia; Kira Orlovsky; Carlo M Croce; Tatsuya Nakamura; Alex Mazo; Lea Eisenbach; Eli Canaani
Journal:  Mol Cell Biol       Date:  2006-12-18       Impact factor: 4.272

2.  PTIP associates with MLL3- and MLL4-containing histone H3 lysine 4 methyltransferase complex.

Authors:  Young-Wook Cho; Teresa Hong; Sunhwa Hong; Hong Guo; Hong Yu; Doyeob Kim; Tad Guszczynski; Gregory R Dressler; Terry D Copeland; Markus Kalkum; Kai Ge
Journal:  J Biol Chem       Date:  2007-05-11       Impact factor: 5.157

3.  Preparation of nuclear and cytoplasmic extracts from mammalian cells.

Authors:  Susan M Abmayr; Tingting Yao; Tari Parmely; Jerry L Workman
Journal:  Curr Protoc Mol Biol       Date:  2006-08

4.  Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae.

Authors:  S D Briggs; M Bryk; B D Strahl; W L Cheung; J K Davie; S Y Dent; F Winston; C D Allis
Journal:  Genes Dev       Date:  2001-12-15       Impact factor: 11.361

5.  COMPASS: a complex of proteins associated with a trithorax-related SET domain protein.

Authors:  T Miller; N J Krogan; J Dover; H Erdjument-Bromage; P Tempst; M Johnston; J F Greenblatt; A Shilatifard
Journal:  Proc Natl Acad Sci U S A       Date:  2001-10-30       Impact factor: 11.205

6.  The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4.

Authors:  A Roguev; D Schaft; A Shevchenko; W W Pijnappel; M Wilm; R Aasland; A F Stewart
Journal:  EMBO J       Date:  2001-12-17       Impact factor: 11.598

7.  MLL targets SET domain methyltransferase activity to Hox gene promoters.

Authors:  Thomas A Milne; Scott D Briggs; Hugh W Brock; Mary Ellen Martin; Denise Gibbs; C David Allis; Jay L Hess
Journal:  Mol Cell       Date:  2002-11       Impact factor: 17.970

8.  Identification and characterization of the human Set1B histone H3-Lys4 methyltransferase complex.

Authors:  Jeong-Heon Lee; Courtney M Tate; Jin-Sam You; David G Skalnik
Journal:  J Biol Chem       Date:  2007-03-13       Impact factor: 5.157

9.  The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.

Authors:  Sanjeevkumar R Patel; Doyeob Kim; Inna Levitan; Gregory R Dressler
Journal:  Dev Cell       Date:  2007-10       Impact factor: 12.270

10.  Identification of JmjC domain-containing UTX and JMJD3 as histone H3 lysine 27 demethylases.

Authors:  Sunhwa Hong; Young-Wook Cho; Li-Rong Yu; Hong Yu; Timothy D Veenstra; Kai Ge
Journal:  Proc Natl Acad Sci U S A       Date:  2007-11-14       Impact factor: 11.205
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  10 in total

1.  Mutant p53 regulates enhancer-associated H3K4 monomethylation through interactions with the methyltransferase MLL4.

Authors:  Homa Rahnamoun; Juyeong Hong; Zhengxi Sun; Jihoon Lee; Hanbin Lu; Shannon M Lauberth
Journal:  J Biol Chem       Date:  2018-06-28       Impact factor: 5.157

Review 2.  Histone H3 lysine 4 methyltransferase KMT2D.

Authors:  Eugene Froimchuk; Younghoon Jang; Kai Ge
Journal:  Gene       Date:  2017-06-29       Impact factor: 3.688

Review 3.  Epigenetic regulation of adipogenesis by histone methylation.

Authors:  Kai Ge
Journal:  Biochim Biophys Acta       Date:  2012-01-04

4.  KDM6A promotes chondrogenic differentiation of periodontal ligament stem cells by demethylation of SOX9.

Authors:  Pingting Wang; Yanjing Li; Tingting Meng; Junjiang Zhang; Yuanyuan Wei; Zhaosong Meng; Yunfeng Lin; Dayong Liu; Lei Sui
Journal:  Cell Prolif       Date:  2017-11-23       Impact factor: 6.831

5.  RAP1-mediated MEK/ERK pathway defects in Kabuki syndrome.

Authors:  Nina Bögershausen; I-Chun Tsai; Esther Pohl; Pelin Özlem Simsek Kiper; Filippo Beleggia; E Ferda Percin; Katharina Keupp; Angela Matchan; Esther Milz; Yasemin Alanay; Hülya Kayserili; Yicheng Liu; Siddharth Banka; Andrea Kranz; Martin Zenker; Dagmar Wieczorek; Nursel Elcioglu; Paolo Prontera; Stanislas Lyonnet; Thomas Meitinger; A Francis Stewart; Dian Donnai; Tim M Strom; Koray Boduroglu; Gökhan Yigit; Yun Li; Nicholas Katsanis; Bernd Wollnik
Journal:  J Clin Invest       Date:  2015-08-17       Impact factor: 14.808

6.  The DNA damage- and transcription-associated protein paxip1 controls thymocyte development and emigration.

Authors:  Elsa Callen; Robert B Faryabi; Megan Luckey; Bingtao Hao; Jeremy A Daniel; Wenjing Yang; Hong-Wei Sun; Greg Dressler; Weiqun Peng; Hongbo Chi; Kai Ge; Michael S Krangel; Jung-Hyun Park; André Nussenzweig
Journal:  Immunity       Date:  2012-11-15       Impact factor: 31.745

7.  Histone methyltransferase MLL3 contributes to genome-scale circadian transcription.

Authors:  Utham K Valekunja; Rachel S Edgar; Malgorzata Oklejewicz; Gijsbertus T J van der Horst; John S O'Neill; Filippo Tamanini; Daniel J Turner; Akhilesh B Reddy
Journal:  Proc Natl Acad Sci U S A       Date:  2013-01-07       Impact factor: 11.205

Review 8.  Transcriptional and epigenetic regulation of PPARγ expression during adipogenesis.

Authors:  Ji-Eun Lee; Kai Ge
Journal:  Cell Biosci       Date:  2014-05-29       Impact factor: 7.133

9.  H3K4 mono- and di-methyltransferase MLL4 is required for enhancer activation during cell differentiation.

Authors:  Ji-Eun Lee; Chaochen Wang; Shiliyang Xu; Young-Wook Cho; Lifeng Wang; Xuesong Feng; Anne Baldridge; Vittorio Sartorelli; Lenan Zhuang; Weiqun Peng; Kai Ge
Journal:  Elife       Date:  2013-12-24       Impact factor: 8.140

10.  Enhancer Reprogramming Confers Dependence on Glycolysis and IGF Signaling in KMT2D Mutant Melanoma.

Authors:  Mayinuer Maitituoheti; Emily Z Keung; Ming Tang; Liang Yan; Hunain Alam; Guangchun Han; Anand K Singh; Ayush T Raman; Christopher Terranova; Sharmistha Sarkar; Elias Orouji; Samir B Amin; Sneha Sharma; Maura Williams; Neha S Samant; Mayura Dhamdhere; Norman Zheng; Tara Shah; Amiksha Shah; Jacob B Axelrad; Nazanin E Anvar; Yu-Hsi Lin; Shan Jiang; Edward Q Chang; Davis R Ingram; Wei-Lien Wang; Alexander Lazar; Min Gyu Lee; Florian Muller; Linghua Wang; Haoqiang Ying; Kunal Rai
Journal:  Cell Rep       Date:  2020-10-20       Impact factor: 9.423
  10 in total

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