PURPOSE OF REVIEW: Asthma is a global burden, affecting 5% of the general adult population, of whom approximately 5-10% suffer from severe asthma. Severe asthma is a complex heterogeneous disease entity, with high morbidity and mortality. Increasingly novel techniques in computed tomography (CT) are being used to understand the pathophysiology of severe asthma. The utility and clinical implications of these CT techniques are the focus of this review. RECENT FINDINGS: Novel qualitative and quantitative CT imaging techniques have enabled us to study the large airway architecture in detail, assess the small airway structure, and perform functional analysis of regional ventilation. SUMMARY: Despite advances in CT imaging techniques, there is an urgent need for both proof-of-concept studies and large cross-sectional and longitudinal clinical trials in severe asthma to validate and clinically correlate imaging derived measures. This will extend our current understanding of the pathophysiology of severe asthma, and unravel the structure-function relationship, with the potential to discover novel severe asthma phenotypes and predict mortality, morbidity, and response to existing and novel pharmacological and nonpharmacological therapies.
PURPOSE OF REVIEW: Asthma is a global burden, affecting 5% of the general adult population, of whom approximately 5-10% suffer from severe asthma. Severe asthma is a complex heterogeneous disease entity, with high morbidity and mortality. Increasingly novel techniques in computed tomography (CT) are being used to understand the pathophysiology of severe asthma. The utility and clinical implications of these CT techniques are the focus of this review. RECENT FINDINGS: Novel qualitative and quantitative CT imaging techniques have enabled us to study the large airway architecture in detail, assess the small airway structure, and perform functional analysis of regional ventilation. SUMMARY: Despite advances in CT imaging techniques, there is an urgent need for both proof-of-concept studies and large cross-sectional and longitudinal clinical trials in severe asthma to validate and clinically correlate imaging derived measures. This will extend our current understanding of the pathophysiology of severe asthma, and unravel the structure-function relationship, with the potential to discover novel severe asthma phenotypes and predict mortality, morbidity, and response to existing and novel pharmacological and nonpharmacological therapies.
Authors: Catherine Beigelman-Aubry; André Capderou; Philippe A Grenier; Christian Straus; Marie-Hélène Becquemin; Thomas Similowski; Marc Zelter Journal: Radiology Date: 2002-04 Impact factor: 11.105
Authors: S A Little; M W Sproule; M D Cowan; K J Macleod; M Robertson; J G Love; G W Chalmers; C P McSharry; N C Thomson Journal: Thorax Date: 2002-03 Impact factor: 9.139
Authors: Stefano Guerra; Enrico Lombardi; Debra A Stern; Duane L Sherrill; Dorothy Gilbertson-Dahdal; Courtney M Wheatley-Guy; Eric M Snyder; Anne L Wright; Fernando D Martinez; Wayne J Morgan Journal: Am J Respir Crit Care Med Date: 2020-12-15 Impact factor: 21.405