Literature DB >> 22112056

Molecular mechanisms of retinal pigment epithelium damage and development of age-related macular degeneration.

Kati Kinnunen1, Goran Petrovski, Morten C Moe, András Berta, Kai Kaarniranta.   

Abstract

Age-related macular degeneration (AMD) is attributed to a complex interaction of genetic and environmental factors. It is characterized by degeneration involving the retinal photoreceptors, retinal pigment epithelium (RPE) and Bruch's membrane, as well as alterations in choroidal capillaries. AMD pathogenesis is strongly associated with chronic oxidative stress and inflammation that ultimately lead to protein damage, aggregation and degeneration of RPE. Specific degenerative findings for AMD are accumulation of intracellular lysosomal lipofuscin and extracellular drusens. In this review, we discuss thoroughly RPE-derived mechanisms in AMD pathology.
© 2011 The Authors. Acta Ophthalmologica © 2011 Acta Ophthalmologica Scandinavica Foundation.

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Year:  2011        PMID： 22112056     DOI： 10.1111/j.1755-3768.2011.02179.x

Source DB:  PubMed          Journal:  Acta Ophthalmol        ISSN： 1755-375X            Impact factor:   3.761


  78 in total

1.  Absence of DJ-1 causes age-related retinal abnormalities in association with increased oxidative stress.

Authors:  Vera L Bonilha; Brent A Bell; Mary E Rayborn; Ivy S Samuels; Anna King; Joe G Hollyfield; Chengsong Xie; Huaibin Cai
Journal:  Free Radic Biol Med       Date:  2017-01-11       Impact factor: 7.376

2.  Enhancing RPE Cell-Based Therapy Outcomes for AMD: The Role of Bruch's Membrane.

Authors:  Janosch P Heller; Keith R Martin
Journal:  Transl Vis Sci Technol       Date:  2014-07-03       Impact factor: 3.283

3.  Photoacoustic tomography imaging and estimation of oxygen saturation of hemoglobin in ocular tissue of rabbits.

Authors:  Stella N Hennen; Wenxin Xing; Ying-Bo Shui; Yong Zhou; Jennifer Kalishman; Lisa B Andrews-Kaminsky; Michael A Kass; David C Beebe; Konstantin I Maslov; Lihong V Wang
Journal:  Exp Eye Res       Date:  2015-06-03       Impact factor: 3.467

4.  Differences in the Genetic Susceptibility to Age-Related Macular Degeneration Clinical Subtypes.

Authors:  Ling Shen; Thomas J Hoffmann; Ronald B Melles; Lori C Sakoda; Mark N Kvale; Yambazi Banda; Catherine Schaefer; Neil Risch; Eric Jorgenson
Journal:  Invest Ophthalmol Vis Sci       Date:  2015-07       Impact factor: 4.799

Review 5.  The impact of oxidative stress and inflammation on RPE degeneration in non-neovascular AMD.

Authors:  Sayantan Datta; Marisol Cano; Katayoon Ebrahimi; Lei Wang; James T Handa
Journal:  Prog Retin Eye Res       Date:  2017-03-20       Impact factor: 21.198

Review 6.  [Clinical, morphological and molecular biological characteristics of the aging eye].

Authors:  M R R Böhm; H Thomasen; F Parnitzke; K-P Steuhl
Journal:  Ophthalmologe       Date:  2017-02       Impact factor: 1.059

7.  [Morphological features of myopic choroidal neovascularization: differences to neovascular age-related macular degeneration].

Authors:  W Inhoffen; F Ziemssen
Journal:  Ophthalmologe       Date:  2012-08       Impact factor: 1.059

8.  Translational attenuation differentially alters the fate of disease-associated fibulin proteins.

Authors:  John D Hulleman; William E Balch; Jeffery W Kelly
Journal:  FASEB J       Date:  2012-08-07       Impact factor: 5.191

9.  Expression and regulation of alarmin cytokine IL-1α in human retinal pigment epithelial cells.

Authors:  Zong-Mei Bian; Matthew G Field; Susan G Elner; Victor M Elner
Journal:  Exp Eye Res       Date:  2018-03-15       Impact factor: 3.467

10.  NLRP3 inflammasome activation in retinal pigment epithelial cells by lysosomal destabilization: implications for age-related macular degeneration.

Authors:  Wen Allen Tseng; Thuzar Thein; Kati Kinnunen; Kameran Lashkari; Meredith S Gregory; Patricia A D'Amore; Bruce R Ksander
Journal:  Invest Ophthalmol Vis Sci       Date:  2013-01-07       Impact factor: 4.799
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