Literature DB >> 22111596

Identification of three novel CTL epitopes within nucleocapsid protein of Hantaan virus.

Meiliang Wang1, Yong Zhu, Jiuping Wang, Tongde Lv, Boquan Jin.   

Abstract

Hantaan virus (HTNV) is a member of the Hantavirus genus that causes human hemorrhagic fever with renal syndrome (HFRS) in humans. The CTL response seems to play a key role in control of viral infection, but only a few HTNV epitopes recognized by the CTLs have been reported. Herein, we screened a panel of overlapping peptides covering the HTNV nucleocapsid protein by ELISPOT assays for those that can elicit IFN-γ production in vitro. Three novel CD8(+) CTL epitopes, N197-205 (RYRTAVCGL), N245-253 (KLLPDTAAV), and N258-266 (GPATNRDYL), were defined on the nucleocapsid protein and were found to be restricted by various HLA alleles including A11, A24, and B7. The epitopes were highly conserved among the reported HTNV strains and other hantanviruses, including Dobrava-Belgrade virus and Seoul virus, supporting their potential use in vaccine designs.

Entities:  

Mesh：

Substances：

Year:  2011        PMID： 22111596      PMCID： PMC3234885          DOI： 10.1089/vim.2011.0026

Source DB:  PubMed          Journal:  Viral Immunol        ISSN： 0882-8245            Impact factor:   2.257


  24 in total

1.  Classification of A1- and A24-supertype molecules by analysis of their MHC-peptide binding repertoires.

Authors:  John Sidney; Scott Southwood; Alessandro Sette
Journal:  Immunogenetics       Date:  2005-07-08       Impact factor: 2.846

2.  Specificity and degeneracy in peptide binding to HLA-B7-like class I molecules.

Authors:  J Sidney; S Southwood; M F del Guercio; H M Grey; R W Chesnut; R T Kubo; A Sette
Journal:  J Immunol       Date:  1996-10-15       Impact factor: 5.422

3.  Human memory cytotoxic T-lymphocyte (CTL) responses to Hantaan virus infection: identification of virus-specific and cross-reactive CD8(+) CTL epitopes on nucleocapsid protein.

Authors:  H L Van Epps; C S Schmaljohn; F A Ennis
Journal:  J Virol       Date:  1999-07       Impact factor: 5.103

4.  HLA-A, -B, and -DRB1 polymorphism defined by sequence-based typing of the Han population in Northern China.

Authors:  G Yang; Y-J Deng; S-N Hu; D-Y Wu; S-B Li; J Zhu; B-F Zhu; Y Liu
Journal:  Tissue Antigens       Date:  2006-02

5.  Allelic and haplotypic diversity of HLA-A, -B, -C, -DRB1, and -DQB1 genes in the Korean population.

Authors:  K W Lee; D H Oh; C Lee; S Y Yang
Journal:  Tissue Antigens       Date:  2005-05

6.  Role of specific CD8+ T cells in the severity of a fulminant zoonotic viral hemorrhagic fever, hantavirus pulmonary syndrome.

Authors:  Elizabeth D Kilpatrick; Masanori Terajima; Frederick T Koster; Michelle D Catalina; John Cruz; Francis A Ennis
Journal:  J Immunol       Date:  2004-03-01       Impact factor: 5.422

7.  Dominant influence of an HLA-B27 restricted CD8+ T cell response in mediating HCV clearance and evolution.

Authors:  Christoph Neumann-Haefelin; Susan McKiernan; Scott Ward; Sergei Viazov; Hans Christian Spangenberg; Thomas Killinger; Thomas F Baumert; Natalja Nazarova; Isabelle Sheridan; Oliver Pybus; Fritz von Weizsäcker; Michael Roggendorf; Dermot Kelleher; Paul Klenerman; Hubert E Blum; Robert Thimme
Journal:  Hepatology       Date:  2006-03       Impact factor: 17.425

8.  Human CD8+ T cell memory generation in Puumala hantavirus infection occurs after the acute phase and is associated with boosting of EBV-specific CD8+ memory T cells.

Authors:  Tamara Tuuminen; Eliisa Kekäläinen; Satu Mäkelä; Ilpo Ala-Houhala; Francis A Ennis; Klaus Hedman; Jukka Mustonen; Antti Vaheri; T Petteri Arstila
Journal:  J Immunol       Date:  2007-08-01       Impact factor: 5.422

9.  Original antigenic sin and apoptosis in the pathogenesis of dengue hemorrhagic fever.

Authors:  Juthathip Mongkolsapaya; Wanwisa Dejnirattisai; Xiao-ning Xu; Sirijitt Vasanawathana; Nattaya Tangthawornchaikul; Aroonrung Chairunsri; Siraporn Sawasdivorn; Thaneeya Duangchinda; Tao Dong; Sarah Rowland-Jones; Pa-thai Yenchitsomanus; Andrew McMichael; Prida Malasit; Gavin Screaton
Journal:  Nat Med       Date:  2003-07       Impact factor: 53.440

10.  CD8+ T-cell responses to different HIV proteins have discordant associations with viral load.

Authors:  Photini Kiepiela; Kholiswa Ngumbela; Christina Thobakgale; Dhanwanthie Ramduth; Isobella Honeyborne; Eshia Moodley; Shabashini Reddy; Chantal de Pierres; Zenele Mncube; Nompumelelo Mkhwanazi; Karen Bishop; Mary van der Stok; Kriebashnie Nair; Nasreen Khan; Hayley Crawford; Rebecca Payne; Alasdair Leslie; Julia Prado; Andrew Prendergast; John Frater; Noel McCarthy; Christian Brander; Gerald H Learn; David Nickle; Christine Rousseau; Hoosen Coovadia; James I Mullins; David Heckerman; Bruce D Walker; Philip Goulder
Journal:  Nat Med       Date:  2006-12-17       Impact factor: 53.440
View more
  11 in total

Review 1.  The nucleocapsid protein of hantaviruses: much more than a genome-wrapping protein.

Authors:  Monika Reuter; Detlev H Krüger
Journal:  Virus Genes       Date:  2017-11-20       Impact factor: 2.332

2.  CD8low CD100- T Cells Identify a Novel CD8 T Cell Subset Associated with Viral Control during Human Hantaan Virus Infection.

Authors:  Bei Liu; Ying Ma; Yusi Zhang; Chunmei Zhang; Jing Yi; Ran Zhuang; Haitao Yu; Angang Yang; Yun Zhang; Boquan Jin
Journal:  J Virol       Date:  2015-09-16       Impact factor: 5.103

3.  Hantaan virus infection induces both Th1 and ThGranzyme B+ cell immune responses that associated with viral control and clinical outcome in humans.

Authors:  Ying Ma; Bin Yuan; Ran Zhuang; Yusi Zhang; Bei Liu; Chunmei Zhang; Yun Zhang; Haitao Yu; Jing Yi; Angang Yang; Boquan Jin
Journal:  PLoS Pathog       Date:  2015-04-02       Impact factor: 6.823

Review 4.  Hemorrhagic Fever with Renal Syndrome: Pathogenesis and Clinical Picture.

Authors:  Hong Jiang; Hong Du; Li M Wang; Ping Z Wang; Xue F Bai
Journal:  Front Cell Infect Microbiol       Date:  2016-02-03       Impact factor: 5.293

5.  Screening and Identification of an H-2Kb-Restricted CTL Epitope within the Glycoprotein of Hantaan Virus.

Authors:  Rui-Xue Ma; Lin-Feng Cheng; Qi-Kang Ying; Rong-Rong Liu; Tie-Jun Ma; Xiao-Xiao Zhang; Zi-Yu Liu; Liang Zhang; Wei Ye; Fang-Lin Zhang; Zhi-Kai Xu; Fang Wang; Xing-An Wu
Journal:  Front Cell Infect Microbiol       Date:  2016-11-25       Impact factor: 5.293

6.  Novel Identified HLA-A*0201-Restricted Hantaan Virus Glycoprotein Cytotoxic T-Cell Epitopes Could Effectively Induce Protective Responses in HLA-A2.1/Kb Transgenic Mice May Associate with the Severity of Hemorrhagic Fever with Renal Syndrome.

Authors:  Kang Tang; Linfeng Cheng; Chunmei Zhang; Yusi Zhang; Xuyang Zheng; Yun Zhang; Ran Zhuang; Boquan Jin; Fanglin Zhang; Ying Ma
Journal:  Front Immunol       Date:  2017-12-12       Impact factor: 7.561

7.  Short peptide epitope design from hantaviruses causing HFRS.

Authors:  Sathish Sankar; Mageshbabu Ramamurthy; Balaji Nandagopal; Gopalan Sridharan
Journal:  Bioinformation       Date:  2017-07-31

8.  Long-lived CD8+ T cell responses following Crimean-Congo haemorrhagic fever virus infection.

Authors:  Dominique Goedhals; Janusz T Paweska; Felicity J Burt
Journal:  PLoS Negl Trop Dis       Date:  2017-12-19

9.  Design and synthesis of HLA-A*02-restricted Hantaan virus multiple-antigenic peptide for CD8+ T cells.

Authors:  Yan Ma; Kang Tang; Yusi Zhang; Chunmei Zhang; Yun Zhang; Boquan Jin; Ying Ma
Journal:  Virol J       Date:  2020-01-31       Impact factor: 4.099

10.  HLA-A2 and B35 restricted hantaan virus nucleoprotein CD8+ T-cell epitope-specific immune response correlates with milder disease in hemorrhagic fever with renal syndrome.

Authors:  Ying Ma; Jiuping Wang; Bin Yuan; Meiliang Wang; Yun Zhang; Zhuwei Xu; Chunmei Zhang; Yusi Zhang; Bei Liu; Jing Yi; Kun Yang; Angang Yang; Ran Zhuang; Boquan Jin
Journal:  PLoS Negl Trop Dis       Date:  2013-02-28
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.