BACKGROUND: In Parkinson's disease, sleep disturbance is a common occurrence. METHODS: We evaluated sleep in 10 patients with Parkinson's disease (age, 57.5 ± 9.8 years; disease duration, 12.3 ± 2.7 years) before and after subthalamic nucleus deep brain stimulation using the Parkinson's disease sleep scale and polysomnography. RESULTS: Their total sleep scale scores and daytime sleepiness subscale scores significantly improved after subthalamic nucleus-deep brain stimulation. The novel findings from this study significantly increased normal rapid eye movement sleep, and decreased abnormal rapid eye movement sleep without atonia after deep brain stimulation in patients with Parkinson's disease. The improved total sleep scale score correlated with decreased wakefulness after sleep onset. Moreover, improved daytime sleepiness correlated with increased normal rapid eye movement sleep time. Sleep improvement did not significantly correlate with resolution of motor complication or reduced dopaminergic dosages. CONCLUSIONS: Subthalamic nucleus-deep brain stimulation may have beneficial effects on sleep disturbance in advanced Parkinson's disease by restoring sleep architecture and normal rapid eye movement sleep.
BACKGROUND: In Parkinson's disease, sleep disturbance is a common occurrence. METHODS: We evaluated sleep in 10 patients with Parkinson's disease (age, 57.5 ± 9.8 years; disease duration, 12.3 ± 2.7 years) before and after subthalamic nucleus deep brain stimulation using the Parkinson's disease sleep scale and polysomnography. RESULTS: Their total sleep scale scores and daytime sleepiness subscale scores significantly improved after subthalamic nucleus-deep brain stimulation. The novel findings from this study significantly increased normal rapid eye movement sleep, and decreased abnormal rapid eye movement sleep without atonia after deep brain stimulation in patients with Parkinson's disease. The improved total sleep scale score correlated with decreased wakefulness after sleep onset. Moreover, improved daytime sleepiness correlated with increased normal rapid eye movement sleep time. Sleep improvement did not significantly correlate with resolution of motor complication or reduced dopaminergic dosages. CONCLUSIONS: Subthalamic nucleus-deep brain stimulation may have beneficial effects on sleep disturbance in advanced Parkinson's disease by restoring sleep architecture and normal rapid eye movement sleep.
Authors: Panagiotis Bargiotas; Lukas Eugster; Michael Oberholzer; Ines Debove; M Lenard Lachenmayer; Johannes Mathis; Claudio Pollo; W M Michael Schüpbach; Claudio L Bassetti Journal: PLoS One Date: 2017-12-18 Impact factor: 3.240
Authors: K Ray Chaudhuri; Keyoumars Ashkan; Siddharth Kharkar; Jonathan Richard Ellenbogen; Michael Samuel; Alexandra Rizos; Monty Silverdale Journal: NPJ Parkinsons Dis Date: 2018-05-25
Authors: Haidar S Dafsari; K Ray-Chaudhuri; Keyoumars Ashkan; Lena Sachse; Picabo Mahlstedt; Monty Silverdale; Alexandra Rizos; Marian Strack; Stefanie T Jost; Paul Reker; Michael Samuel; Veerle Visser-Vandewalle; Julian Evans; Angelo Antonini; Pablo Martinez-Martin; Lars Timmermann Journal: J Neurol Date: 2020-03-09 Impact factor: 4.849