Literature DB >> 22108723

Changes in the myocardial interstitium and contribution to the progression of heart failure.

Shaina R Eckhouse1, Francis G Spinale.   

Abstract

The myocardial interstitium is highly organized and orchestrated, whereby small disruptions in composition, spatial relationships, or content lead to altered myocardial systolic and/or diastolic performance. These changes in extracellular matrix structure and function are important in the progression to heart failure in pressure overload hypertrophy, dilated cardiomyopathy, and ischemic heart disease. The myocardial interstitium is not a passive entity, but rather a complex and dynamic microenvironment that represents an important structural and signaling system within the myocardium. Published by Elsevier Inc.

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Year:  2012        PMID： 22108723      PMCID： PMC3227393          DOI： 10.1016/j.hfc.2011.08.012

Source DB:  PubMed          Journal:  Heart Fail Clin        ISSN： 1551-7136            Impact factor:   3.179


  107 in total

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