Literature DB >> 22107877

Mandatory naltrexone treatment prevents relapse among opiate-dependent anesthesiologists returning to practice.

Lisa J Merlo1, William M Greene, Raymond Pomm.   

Abstract

OBJECTIVE: Anesthesiologists with opioid use disorders are at high risk for relapse. In 2005, the impaired professionals monitoring program of the State of Florida implemented a policy whereby anesthesiologists referred for opiate use disorders were contractually obligated to take naltrexone for 2 years. Naltrexone ingestion was witnessed and verified via random urine drugs screens or administered via intramuscular injection.
METHOD: Charts were reviewed for the 11 anesthesiologists who underwent mandated pharmacotherapy with naltrexone, and 11 anesthesiologists who began monitoring immediately before implementation of this policy.
RESULTS: Eight of 11 anesthesiologists who did not take naltrexone experienced a relapse on opiates. Only 1 of 11 anesthesiologists experienced a relapse on opiates after taking naltrexone, whereas another relapsed on an inhalant (nitrous oxide). It is noteworthy that 5 of the 11 anesthesiologists who took naltrexone had relapsed before naltrexone treatment, and 7 of the 11 anesthesiologists who did not take naltrexone experienced multiple documented relapses. Only 1 of the 11 anesthesiologists who did not take naltrexone successfully returned to the practice of anesthesiology. This individual suffered primarily from alcohol dependence, and suspected opiate abuse was never verified. Others who attempted return to anesthesiology (n = 7) suffered a relapse. In comparison, 9 of the 11 anesthesiologists who took naltrexone have returned to the practice of anesthesiology without a relapse (as verified by continued random urine and hair testing).
CONCLUSION: Mandatory naltrexone treatment may provide anesthesiologists with an additional safeguard to successfully return to work.

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Year:  2011        PMID: 22107877      PMCID: PMC3223377          DOI: 10.1097/ADM.0b013e31821852a0

Source DB:  PubMed          Journal:  J Addict Med        ISSN: 1932-0620            Impact factor:   3.702


  25 in total

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4.  Second-hand exposure to aerosolized intravenous anesthetics propofol and fentanyl may cause sensitization and subsequent opiate addiction among anesthesiologists and surgeons.

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9.  Naltrexone implants can completely prevent early (1-month) relapse after opiate detoxification: a pilot study of two cohorts totalling 101 patients with a note on naltrexone blood levels.

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10.  Non-medical use and abuse of commonly prescribed medications.

Authors:  Paula Riggs
Journal:  Curr Med Res Opin       Date:  2008-02-08       Impact factor: 2.580

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  7 in total

Review 1.  Maintenance medication for opiate addiction: the foundation of recovery.

Authors:  Gavin Bart
Journal:  J Addict Dis       Date:  2012

Review 2.  The Association of State Opioid Misuse Prevention Policies With Patient- and Provider-Related Outcomes: A Scoping Review.

Authors:  Amanda I Mauri; Tarlise N Townsend; Rebecca L Haffajee
Journal:  Milbank Q       Date:  2019-12-04       Impact factor: 4.911

Review 3.  Potential uses of naltrexone in emergency department patients with opioid use disorder.

Authors:  Evan Stuart Bradley; David Liss; Stephanie Pepper Carreiro; David Eric Brush; Kavita Babu
Journal:  Clin Toxicol (Phila)       Date:  2019-03-04       Impact factor: 4.467

4.  Open-label Study of Injectable Extended-release Naltrexone (XR-NTX) in Healthcare Professionals With Opioid Dependence.

Authors:  Paul H Earley; Jacqueline Zummo; Asli Memisoglu; Bernard L Silverman; David R Gastfriend
Journal:  J Addict Med       Date:  2017 May/Jun       Impact factor: 3.702

5.  Naltrexone: A History and Future Directions.

Authors:  A Benjamin Srivastava; Mark S Gold
Journal:  Cerebrum       Date:  2018-09-01

Review 6.  [Burnout and dependence among medical personnel timeless and during the COVID-19 pandemic, using surgery and anesthesia as examples].

Authors:  Sofia Rozani; Kyriacos Evangelou; Louisa Schuffert; Elina Hahn; Christos Tsagkaris; Georgios Matis; Marios Papadakis
Journal:  Chirurgie (Heidelb)       Date:  2022-06-23

7.  Improving naltrexone compliance and outcomes with putative pro- dopamine regulator KB220, compared to treatment as usual.

Authors:  Kenneth Blum; Lisa Lott; David Baron; David E Smith; Rajendra D Badgaiyan; Mark S Gold
Journal:  J Syst Integr Neurosci       Date:  2020-05-30
  7 in total

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