Literature DB >> 22105792

Vitamin C treatment promotes mesenchymal stem cell sheet formation and tissue regeneration by elevating telomerase activity.

Fulan Wei1, Cunye Qu, Tieli Song, Gang Ding, Zhipeng Fan, Dayong Liu, Yi Liu, Chunmei Zhang, Songtao Shi, Songlin Wang.   

Abstract

Cell sheet engineering has been developed as an alternative approach to improve mesenchymal stem cell-mediated tissue regeneration. In this study, we found that vitamin C (Vc) was capable of inducing telomerase activity in periodontal ligament stem cells (PDLSCs), leading to the up-regulated expression of extracellular matrix type I collagen, fibronectin, and integrin β1, stem cell markers Oct4, Sox2, and Nanog as well as osteogenic markers RUNX2, ALP, OCN. Under Vc treatment, PDLSCs can form cell sheet structures because of increased cell matrix production. Interestingly, PDLSC sheets demonstrated a significant improvement in tissue regeneration compared with untreated control dissociated PDLSCs and offered an effective treatment for periodontal defects in a swine model. In addition, bone marrow mesenchymal stem cell sheets and umbilical cord mesenchymal stem cell sheets were also well constructed using this method. The development of Vc-mediated mesenchymal stem cell sheets may provide an easy and practical approach for cell-based tissue regeneration.
Copyright © 2011 Wiley Periodicals, Inc.

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Year:  2012        PMID： 22105792      PMCID： PMC3299914          DOI： 10.1002/jcp.24012

Source DB:  PubMed          Journal:  J Cell Physiol        ISSN： 0021-9541            Impact factor:   6.384


  40 in total

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Journal:  Nature       Date:  1962-05-12       Impact factor: 49.962

2.  Functional expression of ion channels in mesenchymal stem cells derived from umbilical cord vein.

Authors:  Kyoung Sun Park; Kyoung Hwa Jung; Seung Hyun Kim; Kyung Suk Kim; Mi Ran Choi; Yangmi Kim; Young Gyu Chai
Journal:  Stem Cells       Date:  2007-05-24       Impact factor: 6.277

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5.  Ascorbic acid induces in vitro proliferation of human subcutaneous adipose tissue derived mesenchymal stem cells with upregulation of embryonic stem cell pluripotency markers Oct4 and SOX 2.

Authors:  Pravin D Potdar; Stephanie B D'Souza
Journal:  Hum Cell       Date:  2010-11       Impact factor: 4.174

6.  Reactive oxygen species enhance differentiation of human embryonic stem cells into mesendodermal lineage.

Authors:  Ae-Ri Ji; Seung-Yup Ku; Myung Soo Cho; Yoon Young Kim; Yong Jin Kim; Sun Kyung Oh; Seok Hyun Kim; Shin Yong Moon; Young Min Choi
Journal:  Exp Mol Med       Date:  2010-03-31       Impact factor: 8.718

7.  Investigation of multipotent postnatal stem cells from human periodontal ligament.

Authors:  Byoung-Moo Seo; Masako Miura; Stan Gronthos; Peter Mark Bartold; Sara Batouli; Jaime Brahim; Marian Young; Pamela Gehron Robey; Cun-Yu Wang; Songtao Shi
Journal:  Lancet       Date:  2004 Jul 10-16       Impact factor: 79.321

8.  Mesenchymal stem cell proliferation and differentiation on an injectable calcium phosphate-chitosan composite scaffold.

Authors:  Jennifer L Moreau; Hockin H K Xu
Journal:  Biomaterials       Date:  2009-02-01       Impact factor: 12.479

9.  Ascorbic acid protects against endogenous oxidative DNA damage in human sperm.

Authors:  C G Fraga; P A Motchnik; M K Shigenaga; H J Helbock; R A Jacob; B N Ames
Journal:  Proc Natl Acad Sci U S A       Date:  1991-12-15       Impact factor: 11.205

10.  Bioengineering of a functional sheet of islet cells for the treatment of diabetes mellitus.

Authors:  Hirofumi Shimizu; Kazuo Ohashi; Rie Utoh; Kazuya Ise; Mitsukazu Gotoh; Masayuki Yamato; Teruo Okano
Journal:  Biomaterials       Date:  2009-08-11       Impact factor: 12.479
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  77 in total

1.  Fabrication of functional three-dimensional tissues by stacking cell sheets in vitro.

Authors:  Yuji Haraguchi; Tatsuya Shimizu; Tadashi Sasagawa; Hidekazu Sekine; Katsuhisa Sakaguchi; Tetsutaro Kikuchi; Waki Sekine; Sachiko Sekiya; Masayuki Yamato; Mitsuo Umezu; Teruo Okano
Journal:  Nat Protoc       Date:  2012-04-05       Impact factor: 13.491

2.  Application of the cell sheet technique in tissue engineering.

Authors:  Guangnan Chen; Yiying Qi; Lie Niu; Tuoyu DI; Jinwei Zhong; Tingting Fang; Weiqi Yan
Journal:  Biomed Rep       Date:  2015-09-29

3.  Cell sheet biofabrication by co-administration of mesenchymal stem cells secretome and vitamin C on thermoresponsive polymer.

Authors:  Behnaz Banimohammad Shotorbani; Helder André; Abolfazl Barzegar; Nosratollah Zarghami; Roya Salehi; Effat Alizadeh
Journal:  J Mater Sci Mater Med       Date:  2018-11-03       Impact factor: 3.896

4.  Functional tooth restoration by allogeneic mesenchymal stem cell-based bio-root regeneration in swine.

Authors:  Fulan Wei; Tieli Song; Gang Ding; Junji Xu; Yi Liu; Dayong Liu; Zhipeng Fan; Chunmei Zhang; Songtao Shi; Songlin Wang
Journal:  Stem Cells Dev       Date:  2013-03-15       Impact factor: 3.272

Review 5.  The Challenge in Using Mesenchymal Stromal Cells for Recellularization of Decellularized Cartilage.

Authors:  Zhao Huang; Owen Godkin; Gundula Schulze-Tanzil
Journal:  Stem Cell Rev Rep       Date:  2017-02       Impact factor: 5.739

Review 6.  A New Chapter for Mesenchymal Stem Cells: Decellularized Extracellular Matrices.

Authors:  Yagiz Anasiz; Riza Koksal Ozgul; Duygu Uckan-Cetinkaya
Journal:  Stem Cell Rev Rep       Date:  2017-10       Impact factor: 5.739

7.  Similarities and differences between porcine mandibular and limb bone marrow mesenchymal stem cells.

Authors:  Brandon Lloyd; Boon Ching Tee; Colwyn Headley; Hany Emam; Susan Mallery; Zongyang Sun
Journal:  Arch Oral Biol       Date:  2017-01-20       Impact factor: 2.633

8.  Cementogenic genes in human periodontal ligament stem cells are downregulated in response to osteogenic stimulation while upregulated by vitamin C treatment.

Authors:  Philippe Gauthier; Zongdong Yu; Quynh T Tran; Fazal-Ur-Rehman Bhatti; Xiaofei Zhu; George T-J Huang
Journal:  Cell Tissue Res       Date:  2016-10-18       Impact factor: 5.249

9.  Cell sheets of human dental pulp stem cells for future application in bone replacement.

Authors:  Ana Clara Fagundes Pedroni; Giovanna Sarra; Natacha Kalline de Oliveira; Maria Stella Moreira; Maria Cristina Zindel Deboni; Márcia Martins Marques
Journal:  Clin Oral Investig       Date:  2018-10-24       Impact factor: 3.573

10.  Ascorbate-dependent impact on cell-derived matrix in modulation of stiffness and rejuvenation of infrapatellar fat derived stem cells toward chondrogenesis.

Authors:  Tyler Pizzute; Ying Zhang; Fan He; Ming Pei
Journal:  Biomed Mater       Date:  2016-08-10       Impact factor: 3.715
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