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Literature DB >> 22105021

Diabetes: insulin signal meets SIRT1 at AKT.

Yoshiyuki Horio.

Abstract

Entities: Disease Gene

Mesh：

Substances：

Year: 2011 PMID： 22105021 DOI： 10.1038/nrendo.2011.208

Source DB: PubMed Journal: Nat Rev Endocrinol ISSN： 1759-5029 Impact factor: 43.330

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9 in total

1. Nicotinamide mononucleotide, a key NAD(+) intermediate, treats the pathophysiology of diet- and age-induced diabetes in mice.

Authors: Jun Yoshino; Kathryn F Mills; Myeong Jin Yoon; Shin-ichiro Imai
Journal: Cell Metab Date: 2011-10-05 Impact factor: 27.287

2. Sirt1 enhances skeletal muscle insulin sensitivity in mice during caloric restriction.

Authors: Simon Schenk; Carrie E McCurdy; Andrew Philp; Mark Z Chen; Michael J Holliday; Gautum K Bandyopadhyay; Olivia Osborn; Keith Baar; Jerrold M Olefsky
Journal: J Clin Invest Date: 2011-10-10 Impact factor: 14.808

3. Hepatic Sirt1 deficiency in mice impairs mTorc2/Akt signaling and results in hyperglycemia, oxidative damage, and insulin resistance.

Authors: Rui-Hong Wang; Hyun-Seok Kim; Cuiying Xiao; Xiaoling Xu; Oksana Gavrilova; Chu-Xia Deng
Journal: J Clin Invest Date: 2011-10-03 Impact factor: 14.808

4. The deacetylase SIRT1 promotes membrane localization and activation of Akt and PDK1 during tumorigenesis and cardiac hypertrophy.

Authors: Nagalingam R Sundaresan; Vinodkumar B Pillai; Don Wolfgeher; Sadhana Samant; Prabhakaran Vasudevan; Vishwas Parekh; Hariharasundaram Raghuraman; John M Cunningham; Madhu Gupta; Mahesh P Gupta
Journal: Sci Signal Date: 2011-07-19 Impact factor: 8.192

5. Reactive oxygen species have a causal role in multiple forms of insulin resistance.

Authors: Nicholas Houstis; Evan D Rosen; Eric S Lander
Journal: Nature Date: 2006-04-13 Impact factor: 49.962

6. Nutrient control of glucose homeostasis through a complex of PGC-1alpha and SIRT1.

Authors: Joseph T Rodgers; Carlos Lerin; Wilhelm Haas; Steven P Gygi; Bruce M Spiegelman; Pere Puigserver
Journal: Nature Date: 2005-03-03 Impact factor: 49.962

7. SIRT1 improves insulin sensitivity under insulin-resistant conditions by repressing PTP1B.

Authors: Cheng Sun; Fang Zhang; Xinjian Ge; Tingting Yan; Xingmiao Chen; Xianglin Shi; Qiwei Zhai
Journal: Cell Metab Date: 2007-10 Impact factor: 27.287

8. Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes.

Authors: Jill C Milne; Philip D Lambert; Simon Schenk; David P Carney; Jesse J Smith; David J Gagne; Lei Jin; Olivier Boss; Robert B Perni; Chi B Vu; Jean E Bemis; Roger Xie; Jeremy S Disch; Pui Yee Ng; Joseph J Nunes; Amy V Lynch; Hongying Yang; Heidi Galonek; Kristine Israelian; Wendy Choy; Andre Iffland; Siva Lavu; Oliver Medvedik; David A Sinclair; Jerrold M Olefsky; Michael R Jirousek; Peter J Elliott; Christoph H Westphal
Journal: Nature Date: 2007-11-29 Impact factor: 49.962

9. A fasting inducible switch modulates gluconeogenesis via activator/coactivator exchange.

Authors: Yi Liu; Renaud Dentin; Danica Chen; Susan Hedrick; Kim Ravnskjaer; Simon Schenk; Jill Milne; David J Meyers; Phil Cole; John Yates; Jerrold Olefsky; Leonard Guarente; Marc Montminy
Journal: Nature Date: 2008-10-05 Impact factor: 49.962