Literature DB >> 22104496

[18F]DPA-714, [18F]PBR111 and [18F]FEDAA1106-selective radioligands for imaging TSPO 18 kDa with PET: automated radiosynthesis on a TRACERLAb FX-FN synthesizer and quality controls.

Bertrand Kuhnast1, Annelaure Damont, Françoise Hinnen, Tony Catarina, Stéphane Demphel, Stéphane Le Helleix, Christine Coulon, Sébastien Goutal, Philippe Gervais, Frédéric Dollé.   

Abstract

Imaging of TSPO 18 kDa with PET is more and more considered as a relevant biomarker of inflammation in numerous diseases. Development of new radiotracers for TSPO 18 kDa has seen acceleration in the last years and the challenge today is to make available large amounts of such a radiotracer in compliance with GMP standards for application in humans. We present in this technical note automated productions of [(18)F]DPA-714, [(18)F]PBR111 and [(18)F]FEDAA1106, three promising radiotracers for TSPO 18 kDa imaging, using a TRACERlab FX-FN synthesizer. This note also includes the quality control data of the validation batches for the manufacturing qualification of clinical production of [(18)F]DPA-714.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 22104496     DOI： 10.1016/j.apradiso.2011.10.015

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  21 in total

1.  Validation of an automatic reference region extraction for the quantification of [18F]DPA-714 in dynamic brain PET studies.

Authors:  Daniel García-Lorenzo; Sonia Lavisse; Claire Leroy; Catriona Wimberley; Benedetta Bodini; Philippe Remy; Mattia Veronese; Federico Turkheimer; Bruno Stankoff; Michel Bottlaender
Journal:  J Cereb Blood Flow Metab       Date:  2017-02-09       Impact factor: 6.200

2.  PET imaging of neuroinflammation in a rat traumatic brain injury model with radiolabeled TSPO ligand DPA-714.

Authors:  Yu Wang; Xuyi Yue; Dale O Kiesewetter; Gang Niu; Gaojun Teng; Xiaoyuan Chen
Journal:  Eur J Nucl Med Mol Imaging       Date:  2014-03-11       Impact factor: 9.236

3.  PET imaging of cannabinoid type 2 receptors with [11C]A-836339 did not evidence changes following neuroinflammation in rats.

Authors:  Geraldine Pottier; Vanessa Gómez-Vallejo; Daniel Padro; Raphaël Boisgard; Frédéric Dollé; Jordi Llop; Alexandra Winkeler; Abraham Martín
Journal:  J Cereb Blood Flow Metab       Date:  2017-01-12       Impact factor: 6.200

4.  [18F]DPA-714 PET imaging of translocator protein TSPO (18 kDa) in the normal and excitotoxically-lesioned nonhuman primate brain.

Authors:  S Lavisse; K Inoue; C Jan; M A Peyronneau; F Petit; S Goutal; J Dauguet; M Guillermier; F Dollé; L Rbah-Vidal; N Van Camp; R Aron-Badin; P Remy; P Hantraye
Journal:  Eur J Nucl Med Mol Imaging       Date:  2014-12-09       Impact factor: 9.236

5.  TSPO imaging-guided characterization of the immunosuppressive myeloid tumor microenvironment in patients with malignant glioma.

Authors:  Bastian Zinnhardt; Michael Müther; Wolfgang Roll; Philipp Backhaus; Astrid Jeibmann; Claudia Foray; Cristina Barca; Christian Döring; Bertrand Tavitian; Frédéric Dollé; Matthias Weckesser; Alexandra Winkeler; Sven Hermann; Stefan Wagner; Heinz Wiendl; Walter Stummer; Andreas H Jacobs; Michael Schäfers; Oliver M Grauer
Journal:  Neuro Oncol       Date:  2020-07-07       Impact factor: 12.300

6.  Imaging of brain TSPO expression in a mouse model of amyotrophic lateral sclerosis with (18)F-DPA-714 and micro-PET/CT.

Authors:  S Gargiulo; S Anzilotti; A R D Coda; M Gramanzini; A Greco; M Panico; A Vinciguerra; A Zannetti; C Vicidomini; F Dollé; G Pignataro; M Quarantelli; L Annunziato; A Brunetti; M Salvatore; S Pappatà
Journal:  Eur J Nucl Med Mol Imaging       Date:  2016-01-27       Impact factor: 9.236

7.  Complete spatial characterisation of N-glycosylation upon striatal neuroinflammation in the rodent brain.

Authors:  Ana Lúcia Rebelo; Francesco Gubinelli; Pauline Roost; Caroline Jan; Emmanuel Brouillet; Nadja Van Camp; Richard R Drake; Radka Saldova; Abhay Pandit
Journal:  J Neuroinflammation       Date:  2021-05-16       Impact factor: 8.322

8.  Optimised GMP-compliant production of [18F]DPA-714 on the Trasis AllinOne module.

Authors:  Klaudia A Cybulska; Vera Bloemers; Lars R Perk; Peter Laverman
Journal:  EJNMMI Radiopharm Chem       Date:  2021-05-26

9.  In vivo evaluation of inflammatory bowel disease with the aid of μPET and the translocator protein 18 kDa radioligand [18F]DPA-714.

Authors:  Nicholas Bernards; Géraldine Pottier; Benoit Thézé; Frédéric Dollé; Raphael Boisgard
Journal:  Mol Imaging Biol       Date:  2015-02       Impact factor: 3.488

10.  [¹⁸F]DPA-714 as a biomarker for positron emission tomography imaging of rheumatoid arthritis in an animal model.

Authors:  Géraldine Pottier; Nicholas Bernards; Frédéric Dollé; Raphael Boisgard
Journal:  Arthritis Res Ther       Date:  2014-03-13       Impact factor: 5.156
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