BACKGROUND: Little research has explored pre-transplantation psychological factors as predictors of outcome after liver or kidney transplantation. Our objective is to determine whether report of depressive symptoms on waiting list predicts outcome of liver and kidney transplantation. METHODS: Patients on waiting list for liver or kidney transplantation were classified for report or non-report of depressive symptoms on waiting list. 339 were transplanted 6 months later on average, and followed prospectively. The main outcome measures were graft failure and mortality 18 months post-transplantation. RESULTS: Among the 339 patients, 51.6% reported depressive symptoms on waiting list, 16.5% had a graft failure and 7.4% died post-transplantation.Report of depressive symptoms on waiting list predicted a 3 to 4-fold decreased risk of graft failure and mortality 18-months post-transplantation, independently from age, gender, current cigarette smoking, anxiety symptoms, main primary diagnosis, UNOS score, number of comorbid diagnoses and history of transplantation. Data were consistent for liver and kidney transplantations. Other baseline predictive factors were: for graft failure, the main primary diagnosis and a shorter length since this diagnosis, and for mortality, older age, male gender and the main primary diagnosis. CONCLUSION: Further studies are needed to understand the underlying mechanisms of the association between report of depressive symptoms on waiting list and decreased risk of graft failure and mortality after transplantation.
BACKGROUND: Little research has explored pre-transplantation psychological factors as predictors of outcome after liver or kidney transplantation. Our objective is to determine whether report of depressive symptoms on waiting list predicts outcome of liver and kidney transplantation. METHODS:Patients on waiting list for liver or kidney transplantation were classified for report or non-report of depressive symptoms on waiting list. 339 were transplanted 6 months later on average, and followed prospectively. The main outcome measures were graft failure and mortality 18 months post-transplantation. RESULTS: Among the 339 patients, 51.6% reported depressive symptoms on waiting list, 16.5% had a graft failure and 7.4% died post-transplantation.Report of depressive symptoms on waiting list predicted a 3 to 4-fold decreased risk of graft failure and mortality 18-months post-transplantation, independently from age, gender, current cigarette smoking, anxiety symptoms, main primary diagnosis, UNOS score, number of comorbid diagnoses and history of transplantation. Data were consistent for liver and kidney transplantations. Other baseline predictive factors were: for graft failure, the main primary diagnosis and a shorter length since this diagnosis, and for mortality, older age, male gender and the main primary diagnosis. CONCLUSION: Further studies are needed to understand the underlying mechanisms of the association between report of depressive symptoms on waiting list and decreased risk of graft failure and mortality after transplantation.
Authors: A López-Navas; A Rios; A Riquelme; L Martínez-Alarcón; J A Pons; M Miras; A SanMartín; P Ramírez; P Parrilla Journal: Transplant Proc Date: 2010 Jan-Feb Impact factor: 1.066
Authors: Chris Dickens; Linda McGowan; Carol Percival; Barbara Tomenson; Lawrence Cotter; Anthony Heagerty; Francis Creed Journal: J Am Coll Cardiol Date: 2007-04-20 Impact factor: 24.094
Authors: Christian Benzing; Nicco Krezdorn; Julia Förster; Andreas Hinz; Felix Krenzien; Georgi Atanasov; Moritz Schmelzle; Hans-Michael Hau; Michael Bartels Journal: HPB (Oxford) Date: 2016-04-20 Impact factor: 3.647
Authors: Mary Amanda Dew; Emily M Rosenberger; Larissa Myaskovsky; Andrea F DiMartini; Annette J DeVito Dabbs; Donna M Posluszny; Jennifer Steel; Galen E Switzer; Diana A Shellmer; Joel B Greenhouse Journal: Transplantation Date: 2015-05 Impact factor: 4.939