AIM: The aim of this study was to evaluate the association between the circulating BMP-4 levels and atherosclerosis in patients with Type 2 diabetes. MATERIAL & METHODS: Serum BMP-4 levels were measured in 174 diabetic patients, and the degree of atherosclerosis was assessed by measuring the carotid intima-media thickness and the cardio-ankle vascular index. RESULTS: Serum BMP-4 levels were inversely correlated with systolic blood pressure, triglycerides, free fatty acids, cardio-ankle vascular index and carotid intima-media thickness. Lower BMP-4 levels were shown to be an independent predictor of the increased cardio-ankle vascular index and carotid intima-media thickness after adjusting for conventional cardiovascular risk factors in patients with Type 2 diabetes. CONCLUSION: Serum BMP-4 levels are inversely associated with surrogate markers of arterial stiffness and carotid atherosclerosis in patients with Type 2 diabetes.
AIM: The aim of this study was to evaluate the association between the circulating BMP-4 levels and atherosclerosis in patients with Type 2 diabetes. MATERIAL & METHODS: Serum BMP-4 levels were measured in 174 diabeticpatients, and the degree of atherosclerosis was assessed by measuring the carotid intima-media thickness and the cardio-ankle vascular index. RESULTS: Serum BMP-4 levels were inversely correlated with systolic blood pressure, triglycerides, free fatty acids, cardio-ankle vascular index and carotid intima-media thickness. Lower BMP-4 levels were shown to be an independent predictor of the increased cardio-ankle vascular index and carotid intima-media thickness after adjusting for conventional cardiovascular risk factors in patients with Type 2 diabetes. CONCLUSION: Serum BMP-4 levels are inversely associated with surrogate markers of arterial stiffness and carotid atherosclerosis in patients with Type 2 diabetes.
Authors: Carlos Ernesto Fernández-García; Stephania C Isaza; Esther Rey; Patricia Marañón; Rocío Gallego-Durán; Rocío Montero-Vallejo; Javier Rodríguez de Cía; Javier Ampuero; Manuel Romero-Gómez; Carmelo García-Monzón; Águeda González-Rodríguez Journal: Biomark Res Date: 2022-05-25
Authors: Nicholas W Morrell; Donald B Bloch; Peter ten Dijke; Marie-Jose T H Goumans; Akiko Hata; Jim Smith; Paul B Yu; Kenneth D Bloch Journal: Nat Rev Cardiol Date: 2015-10-13 Impact factor: 32.419