PURPOSE: To assess the proportion as well as predictors of anal dysplasia in HIV-infected Asian/Pacific Islanders. METHODS: This was a retrospective chart review evaluating the proportion of anal dysplasia among a multiethnic population from an ambulatory university-based HIV clinic in Hawaii. Demographic, clinical, and virologic parameters were examined with respect to abnormal anal Pap smear. Variables included: Pap smear results (outcome variable), cytology results, age, self-reported ethnicity, CD4/ nadir CD4 counts, HIV viral load, antiretroviral therapy use, Hepatitis B and C co-infections, history of sexually transmitted diseases, personal history of cancer, tobacco use, alcohol use, intravenous drug abuse, family history of cancer, and history of genital/anal warts. RESULTS: There were no significant differences in rates of abnormal Pap smear among the ethnic groups. Abnormal Pap smears were associated with history of genital warts (7% normal vs. 18% abnormal, p=.01) and alcohol consumption (16% vs. 27%, p=.05). Hepatitis B infection and current anti-retroviral therapy (ART) were associated with normal Pap cytology (9.7% vs. 0%, p=.03) and (96.8% vs. 86.5%, p=.05) respectively. CONCLUSIONS: No differences in the proportion of abnormal Pap smears were seen among ethnic groups followed within an ambulatory HIV clinic.
PURPOSE: To assess the proportion as well as predictors of anal dysplasia in HIV-infected Asian/Pacific Islanders. METHODS: This was a retrospective chart review evaluating the proportion of anal dysplasia among a multiethnic population from an ambulatory university-based HIV clinic in Hawaii. Demographic, clinical, and virologic parameters were examined with respect to abnormal anal Pap smear. Variables included: Pap smear results (outcome variable), cytology results, age, self-reported ethnicity, CD4/ nadir CD4 counts, HIV viral load, antiretroviral therapy use, Hepatitis B and C co-infections, history of sexually transmitted diseases, personal history of cancer, tobacco use, alcohol use, intravenous drug abuse, family history of cancer, and history of genital/anal warts. RESULTS: There were no significant differences in rates of abnormal Pap smear among the ethnic groups. Abnormal Pap smears were associated with history of genital warts (7% normal vs. 18% abnormal, p=.01) and alcohol consumption (16% vs. 27%, p=.05). Hepatitis B infection and current anti-retroviral therapy (ART) were associated with normal Pap cytology (9.7% vs. 0%, p=.03) and (96.8% vs. 86.5%, p=.05) respectively. CONCLUSIONS: No differences in the proportion of abnormal Pap smears were seen among ethnic groups followed within an ambulatory HIV clinic.
Authors: Peter V Chin-Hong; Eric Vittinghoff; Ross D Cranston; Lynette Browne; Susan Buchbinder; Grant Colfax; Maria Da Costa; Teresa Darragh; Dana Jones Benet; Franklyn Judson; Beryl Koblin; Kenneth H Mayer; Joel M Palefsky Journal: J Natl Cancer Inst Date: 2005-06-15 Impact factor: 13.506
Authors: Marc T Goodman; Yurii B Shvetsov; Katharine McDuffie; Lynne R Wilkens; Xuemei Zhu; Lily Ning; Jeffrey Killeen; Lori Kamemoto; Brenda Y Hernandez Journal: J Infect Dis Date: 2008-04-01 Impact factor: 5.226
Authors: Ross D Cranston; Teresa M Darragh; Elizabeth A Holly; Naomi Jay; J Michael Berry; Maria Da Costa; Jimmy T Efird; Joel M Palefsky Journal: J Acquir Immune Defic Syndr Date: 2004-08-01 Impact factor: 3.731
Authors: Lana Sue I Ka'opua; Kevin Cassel; Bruce Shiramizu; Rebecca L Stotzer; Andrew Robles; Cathy Kapua; Malulani Orton; Cris Milne; Maddalynn Sesepasara Journal: Health Promot Pract Date: 2015-12-02