Literature DB >> 2210226

Significance of anti-pre-S antibodies in patients with fulminant hepatic failure.

M Irshad1, B M Gandhi, S K Acharya, Y K Joshi, B N Tandon.   

Abstract

Anti-pre-S antibody was tested in 38 sera from patients with fulminant hepatitis (positive for HBsAg and/or IgM anti-HBc) using a specific solid phase enzyme linked immunosorbent assay (ELISA). Anti-pre-S activity was detected in 50 percent sera samples positive for HBsAg but negative for IgM anti-HBc. There were 12.5% sera positive for both HBsAg as well as IgM anti-HBc and 75% sera negative for HBsAg but positive for IgM anti-HBc. The prevalence of HBV-specific DNA-polymerase activity was high in all the three groups whereas anti-HBs positivity was low. Anti-pre-S activity was observed both in the presence as well as in the absence of DNA-polymerase activity. High-anti-pre-S level in fulminant hepatitis B patients was assumed to be implicated in the fast clearance of HBsAg from circulation.

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Year:  1990        PMID： 2210226     DOI： 10.1007/bf02779341

Source DB:  PubMed          Journal:  Gastroenterol Jpn        ISSN： 0435-1339


  10 in total

1.  Antibody to the receptor for polymerized human serum albumin in acute and persistent infection with hepatitis B virus.

Authors:  H Okamoto; S Usuda; M Imai; K Tachibana; E Tanaka; T Kumakura; M Itabashi; E Takai; F Tsuda; T Nakamura
Journal:  Hepatology       Date:  1986 May-Jun       Impact factor: 17.425

2.  Enhanced immunogenicity of the pre-S region of hepatitis B surface antigen.

Authors:  D R Milich; G B Thornton; A R Neurath; S B Kent; M L Michel; P Tiollais; F V Chisari
Journal:  Science       Date:  1985-06-07       Impact factor: 47.728

3.  The enigma of fulminant viral hepatitis.

Authors:  A J Zuckerman
Journal:  Hepatology       Date:  1984 May-Jun       Impact factor: 17.425

4.  Hepatitis B antigen (HBSAg) and/or antibodies (anti-HBS and anti-HBC) in fulminant hepatitis: pathogenic and prognostic significance.

Authors:  C G Trepo; D Robert; J Motin; D Trepo; M Sepetjian; A M Prince
Journal:  Gut       Date:  1976-01       Impact factor: 23.059

5.  Studies on HBsAg binding with polymerised human serum albumin by ELISA.

Authors:  M Irshad; B M Gandhi; T C Chawla; S K Acharya; Y K Joshi; B N Tandon
Journal:  J Virol Methods       Date:  1987-05       Impact factor: 2.014

6.  Multiplication of hepatitis B virus in fulminant hepatitis B.

Authors:  C Brechot; J Bernuau; V Thiers; F Dubois; A Goudeau; B Rueff; P Tiollais; J P Benhamou
Journal:  Br Med J (Clin Res Ed)       Date:  1984-01-28

7.  Anti-pre-S antibodies in different groups of patients with hepatitis B virus infection.

Authors:  M Irshad; B M Gandhi; S K Acharya; Y K Joshi; B N Tandon
Journal:  J Gastroenterol Hepatol       Date:  1989 Jan-Feb       Impact factor: 4.029

8.  A modified technique for the detection of hepatitis B virus-specific DNA polymerase.

Authors:  C T Fang; N Nath; M Pielech; R Y Dodd
Journal:  J Virol Methods       Date:  1981-06       Impact factor: 2.014

9.  Detection of antibodies against pre-S1 proteins in sera of patients with hepatitis B virus (HBV) infection.

Authors:  L Theilmann; M Q Klinkert; K Gmelin; B Kommerell; E Pfaff
Journal:  J Hepatol       Date:  1987-02       Impact factor: 25.083

10.  An antibody which precipitates Dane particles in acute hepatitis type B: relation to receptor sites which bind polymerized human serum albumin on virus particles.

Authors:  A Alberti; P Pontisso; E Schiavon; G Realdi
Journal:  Hepatology       Date:  1984 Mar-Apr       Impact factor: 17.425
  10 in total

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