Literature DB >> 22102249

Preliminary neutron crystallographic study of human transthyretin.

Melina Haupt1, Matthew P Blakeley, Susana C M Teixeira, Sax A Mason, Edward P Mitchell, Jonathan B Cooper, V Trevor Forsyth.   

Abstract

Preliminary studies of perdeuterated crystals of human transthyretin (TTR) have been carried out using the LADI-III and D19 diffractometers at the Institut Laue-Langevin in Grenoble. The results demonstrate the feasibility of a full crystallographic analysis to a resolution of 2.0 Å using Laue diffraction and also illustrate the potential of using monochromatic instruments such as D19 for higher resolution studies where larger crystals having smaller unit cells are available. This study will yield important information on hydrogen bonding, amino-acid protonation states and hydration in the protein. Such information will be of general interest for an understanding of the factors that stabilize/destabilize TTR and for the design of ligands that may be used to counter TTR amyloid fibrillogenesis.
© 2011 International Union of Crystallography. All rights reserved.

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Year:  2011        PMID： 22102249      PMCID： PMC3212468          DOI： 10.1107/S1744309111036244

Source DB:  PubMed          Journal:  Acta Crystallogr Sect F Struct Biol Cryst Commun        ISSN： 1744-3091


  31 in total

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Journal:  Angew Chem Int Ed Engl       Date:  2011-05-23       Impact factor: 15.336

2.  Common core structure of amyloid fibrils by synchrotron X-ray diffraction.

Authors:  M Sunde; L C Serpell; M Bartlam; P E Fraser; M B Pepys; C C Blake
Journal:  J Mol Biol       Date:  1997-10-31       Impact factor: 5.469

3.  Variant-sequence transthyretin (isoleucine 122) in late-onset cardiac amyloidosis in black Americans.

Authors:  D R Jacobson; R D Pastore; R Yaghoubian; I Kane; G Gallo; F S Buck; J N Buxbaum
Journal:  N Engl J Med       Date:  1997-02-13       Impact factor: 91.245

4.  Fibril in senile systemic amyloidosis is derived from normal transthyretin.

Authors:  P Westermark; K Sletten; B Johansson; G G Cornwell
Journal:  Proc Natl Acad Sci U S A       Date:  1990-04       Impact factor: 11.205

5.  Biochemical effect of liver transplantation in two Swedish patients with familial amyloidotic polyneuropathy (FAP-met30).

Authors:  G Holmgren; L Steen; J Ekstedt; C G Groth; B G Ericzon; S Eriksson; O Andersen; I Karlberg; G Nordén; M Nakazato
Journal:  Clin Genet       Date:  1991-09       Impact factor: 4.438

6.  Structure of prealbumin: secondary, tertiary and quaternary interactions determined by Fourier refinement at 1.8 A.

Authors:  C C Blake; M J Geisow; S J Oatley; B Rérat; C Rérat
Journal:  J Mol Biol       Date:  1978-05-25       Impact factor: 5.469

7.  Clinical improvement and amyloid regression after liver transplantation in hereditary transthyretin amyloidosis.

Authors:  G Holmgren; B G Ericzon; C G Groth; L Steen; O Suhr; O Andersen; B G Wallin; A Seymour; S Richardson; P N Hawkins
Journal:  Lancet       Date:  1993-05-01       Impact factor: 79.321

8.  Tabulation of human transthyretin (TTR) variants, 2003.

Authors:  Lawreen Heller Connors; Amareth Lim; Tatiana Prokaeva; Violet A Roskens; Catherine E Costello
Journal:  Amyloid       Date:  2003-09       Impact factor: 7.141

Review 9.  The integration of macromolecular diffraction data.

Authors:  Andrew G W Leslie
Journal:  Acta Crystallogr D Biol Crystallogr       Date:  2005-12-14

Review 10.  Amyloidosis.

Authors:  Mark B Pepys
Journal:  Annu Rev Med       Date:  2006       Impact factor: 13.739
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2.  Back-exchange of deuterium in neutron crystallography: characterization by IR spectroscopy.

Authors:  Ai Woon Yee; Matthew P Blakeley; Martine Moulin; Michael Haertlein; Edward Mitchell; V Trevor Forsyth
Journal:  J Appl Crystallogr       Date:  2017-03-24       Impact factor: 3.304

3.  Binding site asymmetry in human transthyretin: insights from a joint neutron and X-ray crystallographic analysis using perdeuterated protein.

Authors:  Melina Haupt; Matthew P Blakeley; Stuart J Fisher; Sax A Mason; Jon B Cooper; Edward P Mitchell; V Trevor Forsyth
Journal:  IUCrJ       Date:  2014-10-21       Impact factor: 4.769
  3 in total

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