Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Antigen recognition by antibody C836 through adjustment of V(L)/V(H) packing.

Literature DB >> 22102019

Antigen recognition by antibody C836 through adjustment of V(L)/V(H) packing.

Alexey Teplyakov¹, Galina Obmolova, Thomas Malia, Gary Gilliland.

Abstract

C836 is a neutralizing monoclonal antibody to human interleukin IL-13 generated by mouse immunization. The crystal structure of the C836 Fab was determined at 2.5 Å resolution and compared with the IL-13-bound form determined previously. This comparison indicates an induced-fit mechanism of antigen recognition through rigid-body rotation of the V(L) and V(H) domains. The magnitude of this rearrangement is one of the largest observed for antibody-protein interactions.

Entities: Gene Species

Mesh：

Substances：

Year: 2011 PMID： 22102019 PMCID： PMC3212354 DOI： 10.1107/S1744309111027746

Source DB: PubMed Journal: Acta Crystallogr Sect F Struct Biol Cryst Commun ISSN： 1744-3091

25 in total

Review 1. Unraveling hot spots in binding interfaces: progress and challenges.

Authors: Warren L DeLano
Journal: Curr Opin Struct Biol Date: 2002-02 Impact factor: 6.809

2. Structural evidence for induced fit as a mechanism for antibody-antigen recognition.

Authors: J M Rini; U Schulze-Gahmen; I A Wilson
Journal: Science Date: 1992-02-21 Impact factor: 47.728

3. Small rearrangements in structures of Fv and Fab fragments of antibody D1.3 on antigen binding.

Authors: T N Bhat; G A Bentley; T O Fischmann; G Boulot; R J Poljak
Journal: Nature Date: 1990-10-04 Impact factor: 49.962

4. Analysis and prediction of VH/VL packing in antibodies.

Authors: K R Abhinandan; Andrew C R Martin
Journal: Protein Eng Des Sel Date: 2010-06-30 Impact factor: 1.650

Review 5. Structure of antibody-antigen complexes: implications for immune recognition.

Authors: P M Colman
Journal: Adv Immunol Date: 1988 Impact factor: 3.543

6. Major antigen-induced domain rearrangements in an antibody.

Authors: R L Stanfield; M Takimoto-Kamimura; J M Rini; A T Profy; I A Wilson
Journal: Structure Date: 1993-10-15 Impact factor: 5.006

7. Anti-IL-13 monoclonal antibody inhibits airway hyperresponsiveness, inflammation and airway remodeling.

Authors: Gaoyun Yang; Amy Volk; Ted Petley; Eva Emmell; Jill Giles-Komar; Xiaozhou Shang; Jian Li; Anuk M Das; Dave Shealy; Don E Griswold; Li Li
Journal: Cytokine Date: 2004-12-21 Impact factor: 3.861

8. On the domain pairing in chimeric antibodies.

Authors: Alexey Teplyakov; Galina Obmolova; Jill M Carton; Wei Gao; Yonghong Zhao; Gary L Gilliland
Journal: Mol Immunol Date: 2010-08 Impact factor: 4.407

9. Overview of the CCP4 suite and current developments.

Authors: Martyn D Winn; Charles C Ballard; Kevin D Cowtan; Eleanor J Dodson; Paul Emsley; Phil R Evans; Ronan M Keegan; Eugene B Krissinel; Andrew G W Leslie; Airlie McCoy; Stuart J McNicholas; Garib N Murshudov; Navraj S Pannu; Elizabeth A Potterton; Harold R Powell; Randy J Read; Alexei Vagin; Keith S Wilson
Journal: Acta Crystallogr D Biol Crystallogr Date: 2011-03-18

10. MolProbity: all-atom structure validation for macromolecular crystallography.

Authors: Vincent B Chen; W Bryan Arendall; Jeffrey J Headd; Daniel A Keedy; Robert M Immormino; Gary J Kapral; Laura W Murray; Jane S Richardson; David C Richardson
Journal: Acta Crystallogr D Biol Crystallogr Date: 2009-12-21

6 in total

1. Quantitative Analysis of the Association Angle between T-cell Receptor Vα/Vβ Domains Reveals Important Features for Epitope Recognition.

Authors: Thomas Hoffmann; Angela M Krackhardt; Iris Antes
Journal: PLoS Comput Biol Date: 2015-07-17 Impact factor: 4.475