Literature DB >> 22101864

Pseudogenes of rat VDAC1: 16 gene segments in the rat genome show structural similarities with the cDNA encoding rat VDAC1, with 8 slightly expressed in certain tissues.

Yusuke Ido1, Takenori Yamamoto, Tatsuki Yoshitomi, Atsushi Yamamoto, Eriko Obana, Kazuto Ohkura, Yasuo Shinohara.   

Abstract

BLAST analysis of the rat genome revealed the presence of 16 pseudogenes of isoform 1 of the mitochondrial voltage-dependent anion channel (VDAC1). Based on their structural characterization, it was concluded that these pseudogenes were formed by integration of VDAC1 cDNA into the genome, and subsequent rearrangements/mutations. By RT-PCR analysis using carefully designed primers that could not amplify the cDNA of genuine VDAC1, 8 of these 16 pseudogenes showed slight expression in certain tissues, but none of them seemed to encode a functional protein.

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Year:  2011        PMID： 22101864     DOI： 10.1007/s00335-011-9375-x

Source DB:  PubMed          Journal:  Mamm Genome        ISSN： 0938-8990            Impact factor:   2.957


  17 in total

Review 1.  Vertebrate pseudogenes.

Authors:  A J Mighell; N R Smith; P A Robinson; A F Markham
Journal:  FEBS Lett       Date:  2000-02-25       Impact factor: 4.124

Review 2.  VDAC channels.

Authors:  E Blachly-Dyson; M Forte
Journal:  IUBMB Life       Date:  2001 Sep-Nov       Impact factor: 3.885

3.  Characterization of porin isoforms expressed in tumor cells.

Authors:  Y Shinohara; T Ishida; M Hino; N Yamazaki; Y Baba; H Terada
Journal:  Eur J Biochem       Date:  2000-10

4.  The murine voltage-dependent anion channel gene family. Conserved structure and function.

Authors:  M J Sampson; R S Lovell; W J Craigen
Journal:  J Biol Chem       Date:  1997-07-25       Impact factor: 5.157

5.  All three isoforms of the voltage-dependent anion channel (VDAC1, VDAC2, and VDAC3) are present in mitochondria from bovine, rabbit, and rat brain.

Authors:  Marcelo de Cerqueira Cesar; John E Wilson
Journal:  Arch Biochem Biophys       Date:  2004-02-15       Impact factor: 4.013

6.  VDAC1, having a shorter N-terminus than VDAC2 but showing the same migration in an SDS-polyacrylamide gel, is the predominant form expressed in mitochondria of various tissues.

Authors:  Takenori Yamamoto; Akiko Yamada; Masahiro Watanabe; Yuya Yoshimura; Naoshi Yamazaki; Yoshiyuki Yoshimura; Takashi Yamauchi; Masatoshi Kataoka; Toshihiko Nagata; Hiroshi Terada; Yasuo Shinohara
Journal:  J Proteome Res       Date:  2006-12       Impact factor: 4.466

Review 7.  Measurement of VDAC permeability in intact mitochondria and in reconstituted systems.

Authors:  Marco Colombini
Journal:  Methods Cell Biol       Date:  2007       Impact factor: 1.441

8.  Classification of FABP isoforms and tissues based on quantitative evaluation of transcript levels of these isoforms in various rat tissues.

Authors:  Takenori Yamamoto; Atsushi Yamamoto; Masahiro Watanabe; Taisuke Matsuo; Naoshi Yamazaki; Masatoshi Kataoka; Hiroshi Terada; Yasuo Shinohara
Journal:  Biotechnol Lett       Date:  2009-06-30       Impact factor: 2.461

Review 9.  The mitochondrial transporter family (SLC25): physiological and pathological implications.

Authors:  Ferdinando Palmieri
Journal:  Pflugers Arch       Date:  2003-11-04       Impact factor: 3.657

10.  Mapping of the human Voltage-Dependent Anion Channel isoforms 1 and 2 reconsidered.

Authors:  A Messina; M Oliva; C Rosato; M Huizing; W Ruitenbeek; L P van den Heuvel; M Forte; M Rocchi; V De Pinto
Journal:  Biochem Biophys Res Commun       Date:  1999-02-24       Impact factor: 3.575
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  1 in total

1.  Differential expression of transcription factors and inflammation-, ROS-, and cell death-related genes in organotypic cultures in the modiolus, the organ of Corti and the stria vascularis of newborn rats.

Authors:  Johann Gross; Heidi Olze; Birgit Mazurek
Journal:  Cell Mol Neurobiol       Date:  2014-03-05       Impact factor: 5.046
  1 in total

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