Literature DB >> 22101801

Preparation and investigation of bioactive transferrin-iron complexes formed with different synergistic anions.

Judit Gálicza1, Andrea Vargová, Viktor Sándor, Csongor Kálmán Orbán, Csaba Dezso András, Beáta Abrahám, Szabolcs Lányi, Ferenc Kilár.   

Abstract

Human serum transferrin has a potential for drug-delivery systems. Oxalate and aziridine-carboxylate was conjugated to serum transferrin in order to transport into the targeted cancer cells via transferrin-receptor mediated endocytosis. Capillary zone electrophoresis and capillary isoelectric focusing were used to analyze the effectiveness of complexation reactions. The electropherograms show the differences between iron-free- and iron-complexed molecular forms of human serum transferrin. The iron-complexed transferrin sample containing the different anions as synergistic complexing agents were characterized by different electrophoretic parameters.

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Year:  2012        PMID： 22101801     DOI： 10.1007/s10930-011-9370-9

Source DB:  PubMed          Journal:  Protein J        ISSN： 1572-3887            Impact factor:   2.371


  28 in total

1.  Influence of conjugation of doxorubicin to transferrin on the iron uptake by K562 cells via receptor-mediated endocytosis.

Authors:  A Bérczi; M Ruthner; V Szüts; M Fritzer; E Schweinzer; H Goldenberg
Journal:  Eur J Biochem       Date:  1993-04-01

2.  Synthesis of transferrin-mitomycin C conjugate as a receptor-mediated drug targeting system.

Authors:  T Tanaka; Y Kaneo; M Miyashita
Journal:  Biol Pharm Bull       Date:  1996-05       Impact factor: 2.233

3.  Isoforms and levels of transferrin, antithrombin, alpha(1)-antitrypsin and thyroxine-binding globulin in 48 patients with carbohydrate-deficient glycoprotein syndrome type I.

Authors:  H Stibler; U Holzbach; B Kristiansson
Journal:  Scand J Clin Lab Invest       Date:  1998-02       Impact factor: 1.713

4.  The position of arginine 124 controls the rate of iron release from the N-lobe of human serum transferrin. A structural study.

Authors:  Ty E Adams; Anne B Mason; Qing-Yu He; Peter J Halbrooks; Sara K Briggs; Valerie C Smith; Ross T A MacGillivray; Stephen J Everse
Journal:  J Biol Chem       Date:  2002-11-27       Impact factor: 5.157

5.  The influence of the synergistic anion on iron chelation by ferric binding protein, a bacterial transferrin.

Authors:  Suraj Dhungana; Celine H Taboy; Damon S Anderson; Kevin G Vaughan; Philip Aisen; Timothy A Mietzner; Alvin L Crumbliss
Journal:  Proc Natl Acad Sci U S A       Date:  2003-03-19       Impact factor: 11.205

6.  Apoptosis induced by oxalate in human renal tubular epithelial HK-2 cells.

Authors:  Byong-Chang Jeong; Cheol Kwak; Kyu Seon Cho; Bong Sub Kim; Sung Kyu Hong; Jung-In Kim; Chongwook Lee; Hyeon Hoe Kim
Journal:  Urol Res       Date:  2005-03-10

7.  The complete amino acid sequence of human serum transferrin.

Authors:  R T MacGillivray; E Mendez; S K Sinha; M R Sutton; J Lineback-Zins; K Brew
Journal:  Proc Natl Acad Sci U S A       Date:  1982-04       Impact factor: 11.205

8.  Apoptosis and its related genes in renal epithelial cells of the stone-forming rat.

Authors:  Katsuhito Miyazawa; Koji Suzuki; Ryosuke Ikeda; Manabu T Moriyama; Yoshimichi Ueda; Shogo Katsuda
Journal:  Urol Res       Date:  2004-07-03

9.  Synthesis and anti-cancer activity of covalent conjugates of artemisinin and a transferrin-receptor targeting peptide.

Authors:  Steve Oh; Byung Ju Kim; Narendra P Singh; Henry Lai; Tomikazu Sasaki
Journal:  Cancer Lett       Date:  2008-10-05       Impact factor: 8.679

10.  The oxalate effect on release of iron from human serum transferrin explained.

Authors:  Peter J Halbrooks; Anne B Mason; Ty E Adams; Sara K Briggs; Stephen J Everse
Journal:  J Mol Biol       Date:  2004-05-21       Impact factor: 5.469
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