| Literature DB >> 22100876 |
Abstract
XCL1, a C class chemokine also known as lymphotactin, is produced by T, NK, and NKT cells during infectious and inflammatory responses, whereas XCR1, the receptor of XCL1, is expressed by a dendritic cell subpopulation. The XCL1-XCR1 axis plays an important role in dendritic-cell-mediated cytotoxic immune response. It has been also shown that XCL1 and XCR1 are constitutively expressed in the thymus and regulate the thymic establishment of self-tolerance and the generation of regulatory T cells. This review summarizes the expression and function of XCL1 and XCR1 in the immune system.Entities:
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Year: 2011 PMID： 22100876 DOI： 10.1016/j.micinf.2011.10.003
Source DB: PubMed Journal: Microbes Infect ISSN： 1286-4579 Impact factor: 2.700